Experimental gingivitis, bacteremia and systemic biomarkers: a randomized clinical trial
Experimental gingivitis, bacteremia and systemic biomarkers: a randomized clinical trial
复制标题
DOI：
10.1111/jre.12280
复制
发表时间：
2015-12-01
影响因子：
3.5
通讯作者：
He, T.
中科院分区：
文献类型：
--
作者：
Kinane, D. F.;Zhang, P.;He, T.
菌血症和全身炎症标志物与牙周和全身性疾病相关，可能是这些疾病之间的联系机制。我们假设，在牙龈炎症的发展，炎症和菌血症的全身标志物会increasing.Material和MethodsTo研究菌血症对全身炎症标志物的影响，我们招募了80名受试者参加实验性牙龈炎的研究。受试者根据性别、吸烟和出血部位的数量进行分层，然后随机分为两组：对照组（n=40）或实验性牙龈炎组（n=40）。对照组的受试者进行口腔卫生方案：每天用常规氟化钠防蛀剂和标准手动牙刷刷牙两次，每天用牙线洁牙两次，每天用抗龋氟漱口水漱口一次。实验组停止刷牙和使用牙线，仅使用含氟防龋漱口水21 d。结果80例受试者中有79例可评价。对照组中的1例受试者因研究期间使用抗生素而从结果中排除。实验组与对照组相比，牙龈炎组与对照组相比，差异有显著性（p <0.05）。
Background and ObjectiveBacteremia and systemic inflammatory markers are associated with periodontal and systemic diseases and may be linking mechanisms between these conditions. We hypothesized that in the development of gingival inflammation, systemic markers of inflammation and bacteremia would increase.Material and MethodsTo study the effect of bacteremia on systemic inflammatory markers, we recruited 80 subjects to participate in an experimental gingivitis study. Subjects were stratified based on gender, smoking and the number of bleeding sites and then randomized to one of two groups: control group (n=40) or experimental gingivitis group (n=40). Subjects in the control group conducted an oral hygiene regimen: brushing twice daily with a regular sodium fluoride cavity protection dentifrice and a standard manual toothbrush, flossing twice daily, and mouth rinsing with an anti-cavity fluoride rinse once daily. The experimental group stopped brushing and flossing, and used only the fluoride anti-cavity mouth rinse for 21d.ResultsSeventy-nine of 80 subjects were evaluable. One subject in the control group was excluded from the results due to antibiotic use during the study. Our data showed the experimental gingivitis group exhibited a significant (p