GROWTH KINETICS OF PLASMA-CELL MYELOMA
GROWTH KINETICS OF PLASMA-CELL MYELOMA
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DOI：
10.1093/jnci/58.5.1247
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发表时间：
1977-01-01
影响因子：
10.3
通讯作者：
ALEXANIAN, R
中科院分区：
文献类型：
--
作者：
DREWINKO, B;ALEXANIAN, R
本文比较了128例不同病期多发性骨髓瘤患者血浆细胞标记指数(LI)与肿瘤负荷和治疗时间的关系。肿瘤缩小程度不同的患者LI无显著差异。患者在前3个月内观察。接受治疗的患者的LI显著高于未接受治疗的患者和间隔较长时间后接受研究的患者。用颗粒计数减半的方法对骨髓瘤细胞进行体内细胞周期分析，未能确定细胞周期的长度，但确定了S+G2期的长度大于60h，类似的体外研究定义了较短的S+G2期的组合长度。持续输注[~3H]胸腺嘧啶核苷的2例患者，确定代时为8d。两名患者的初始LI相似(5.7和6.6)，但生长分数不同(19和47%)。测量的肿瘤质量倍增时间比计算的要长得多，这表明存在相当大的内在细胞损失(83%和47%)。这些观察结果由多发性骨髓瘤生长动力学假想的两室模型进行总结。
The plasma cell labeling index(es) (LI) of 128 patients with multiple myeloma at various stages of disease was compared as a function of tumor mass load and length of treatment. No significant differences in LI were noted for patients with various degrees of tumor reduction. Patients observed during the first 3 mo. of treatment had significantly higher LI than did untreated patients and those studied after longer intervals. In vivo cell-cycle analysis of myeloma cells by the halving time of the grain-count method failed to establish the length of the cell cycle but defined the length of S + G2 phases as being longer than 60 h. Similar studies conducted in vitro defined a shorter combined length of S + G2 phase. In 2 patients in whom continuous infusion with [3H]thymidine was performed, the generation time was established as 8 days. Both patients had similar initial LI (5.7 and 6.6) but different growth fractions (19 and 47%). The measured tumor mass doubling time was much longer than the calculated one, suggesting the presence of considerable intrinsic cell loss (83 and 47%). These observations were summarized by a hypothetical 2-compartment model for the growth kinetics of multiple myeloma.