A RANDOMIZED CONTROLLED TRIAL OF COLD-ADAPTED AND INACTIVATED VACCINES FOR THE PREVENTION OF INFLUENZA A DISEASE
A RANDOMIZED CONTROLLED TRIAL OF COLD-ADAPTED AND INACTIVATED VACCINES FOR THE PREVENTION OF INFLUENZA A DISEASE
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DOI：
10.1093/infdis/169.1.68
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发表时间：
1994-01-01
影响因子：
6.4
通讯作者：
WRIGHT, PF
中科院分区：
文献类型：
--
作者：
EDWARDS, KM;DUPONT, WD;WRIGHT, PF
A double-blind, randomized controlled trial over 5 years compared the safety, immunogenicity, and efficacy of cold-adapted and inactivated influenza A vaccines in 5210 normal subjects. Both vaccines were well tolerated. Inactivated vaccine significantly increased hemagglutination inhibition antibody titers. Significant titer rises were also noted after cold-adapted vaccine but of lesser magnitude than with inactivated vaccine. The efficacy of inactivated vaccine in preventing culture-positive influenza was 76% (95% confidence interval [CI], 58%-87%) for H1N1 disease and 74% (95% CI, 52%-86%) for H3N2; for cold-adapted vaccine, 85% (95% CI, 70%-92%) and 58% (95% CI, 29%-75%), respectively. The efficacy of inactivated vaccine in preventing a four-fold rise in antibody titer over the influenza season was 69% (95% CI, 61%-76%) for H1N1 and 73% (95% CI. 65%-79%) for H3N2; for cold-adapted vaccine, 54% (95% CI, 44%-62%) and 32% (95% CI, 17%-44%), respectively. Cold-adapted and inactivated influenza vaccines are safe and effective for preventing influenza A disease.
