Physical activity and insulin sensitivity - the RISC Study
Physical activity and insulin sensitivity - the RISC Study
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DOI：
10.2337/db07-1605
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发表时间：
2008-10-01
期刊：
影响因子：
7.7
通讯作者：
Ferrannini, Ele
中科院分区：
文献类型：
--
作者：
Balkau, Beverley;Mhamdi, Leila;Ferrannini, Ele
体力活动是2型糖尿病的一个可改变的危险因素，部分是通过其对胰岛素敏感性的作用。我们报告胰岛素敏感性和身体活动之间的关系accelerometer.RESEARCH设计和方法，这是一个横断面研究346名男性和455名女性，年龄30-60岁，没有心血管疾病，不治疗糖尿病，高血压，血脂异常，或肥胖症的药物。参与者来自13个欧洲国家的18个临床中心。采用高胰岛素-正葡萄糖钳夹法测定胰岛素敏感性。通过加速度计记录体力活动，平均时间为6天。我们研究了胰岛素敏感性与总活动量（每分钟计数）、久坐时间百分比、轻度活动时间百分比和活动强度（参与者是否记录了一些剧烈或中度活动）的关系。久坐、轻度活动和活动强度的时间也与胰岛素敏感性相关（男性/女性分别为P < 0.0004/0.01、0.002/0.03和0.02/0.004），但一旦调整了总活动量，则失去了显著性。调整混杂因素，如肥胖减弱了与总活动的关系，没有与混杂因素的相互作用。即使在25%的久坐者中，总活动量也与胰岛素敏感性显著相关（P < 0.0001）。结论：累积的每日体力活动是胰岛素敏感性的主要决定因素。久坐不动的时间、轻度活动的时间、中度或剧烈活动的时间不影响胰岛素敏感性，与总活动无关。
OBJECTIVE-Physical activity is a modifiable risk factor for type 2 diabetes, partly through its action on insulin sensitivity. We report the relation between insulin sensitivity and physical activity measured by accelerometry.RESEARCH DESIGN AND METHODS-This is a cross-sectional study of 346 men and 455 women, aged 30-60 years, without cardiovascular disease and not treated by drugs for diabetes, hypertension, dyslipidemia, or obesity. Participants were recruited in 18 clinical centers from 13 European countries. Insulin sensitivity was measured by hyperinsulinemic-euglycemic clamp. Physical activity was recorded by accelerometry for a median of 6 days. We studied the relationship of insulin sensitivity with total activity (in counts per minute), percent of time spent sedentary, percent of time in light activity, and activity intensity (whether the participant recorded some vigorous or some moderate activity).RESULTS-In both men and women, total activity was associated with insulin sensitivity (P < 0.0001). Time spent sedentary, in light activity, and activity intensity was also associated with insulin sensitivity (P < 0.0004/0.01, 0.002/0.03, and 0.02/0.004, respectively, for men/women) but lost significance once adjusted for total activity. Adjustment for confounders such as adiposity attenuated the relationship with total activity; there were no interactions with confounders. Even in the 25% most sedentary individuals, total activity was significantly associated with better insulin sensitivity (P < 0.0001).CONCLUSIONS-Accumulated daily physical activity is a major determinant of insulin sensitivity. Time spent sedentary, time spent in light-activity, and bouts of moderate or vigorous activity did not impact insulin sensitivity independently of total activity.