Daily ingestion of alginate reduces energy intake in free-living subjects
Daily ingestion of alginate reduces energy intake in free-living subjects
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DOI：
10.1016/j.appet.2008.06.013
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发表时间：
2008-11-01
期刊：
影响因子：
5.4
通讯作者：
Corfe, B. M.
中科院分区：
文献类型：
--
作者：
Paxman, J. R.;Richardson, J. C.;Corfe, B. M.
海藻酸钠是一种海藻衍生纤维，此前已被证明可以在急性进食模型中调节食欲。这种作用的机制可能包括胃清除速度减慢和小肠吸收减弱。为了评估海藻酸盐是否可以有效地控制自由生活的成年人的食欲，68 名男性和女性（BMI 范围：18.50-32.81 kgl M-2）完成了这项随机、受控的双向交叉干预，以比较每天摄入强胶凝海藻酸钠制剂 7 天与对照的效果。选择具有高古洛糖醛酸含量的海藻酸钠是因为，摄入后，它在钙离子存在下形成坚固的凝胶。每日餐前摄入海藻酸钠配方可使每日平均能量摄入量显着减少 134.8 kcal (7%)。能量摄入量的减少是通过平均每日碳水化合物、糖、脂肪、饱和脂肪和蛋白质摄入量的显着减少来实现的。预载类型的主效应与性别、BMI 分类和/或预载传递时间的主效应之间不存在任何显着的交互作用，表明这种治疗对于不同环境下的个体的疗效。这些发现表明强胶凝海藻酸钠制剂在未来超重和肥胖的管理中可能发挥作用。 (C) 2008 Elsevier Ltd. 保留所有权利。
Sodium alginate is a seaweed-derived fibre that has previously been shown to moderate appetite in models of acute feeding. The mechanisms underlying this effect may include slowed gastric clearance and attenuated uptake from the small intestine. In order to assess whether alginate could be effective as a means of appetite control in free-living adults, 68 males and females (BMI range: 18.50-32.81 kgl M-2) completed this randomised, controlled two-way crossover intervention to compare the effects of 7 day daily ingestion of a strong-gelling sodium alginate formulation against a control. A sodium alginate with a high-guluronate content was chosen because, upon ingestion, it forms a strong gel in the presence of calcium ions. Daily preprandial ingestion of the sodium alginate formulation produced a significant 134.8 kcal (7%) reduction in mean daily energy intake. This reduced energy intake was underwritten by significant reductions in mean daily carbohydrate, sugar, fat, saturated fat and protein intakes. The absence of any significant interaction effects between the main effect of preload type and those of gender, BMI classification and/or timing of preload delivery indicates the efficacy of this treatment for individuals in different settings. These findings suggest a possible role for a strong-gelling sodium alginate formulation in the future management of overweight and obesity. (C) 2008 Elsevier Ltd. All rights reserved.