Social determinants of depression in systemic lupus erythematosus: A systematic scoping review.

Social determinants of depression in systemic lupus erythematosus: A systematic scoping review.
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DOI:
10.1177/09612033221135145
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发表时间:
2023-01
期刊:
影响因子:
2.6
通讯作者:
--
中科院分区:
医学4区
文献类型:
--
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健康的社会决定因素(SDOH)影响系统性红斑狼疮(SLE)的不平等。虽然这些不平等有助于整体疾病的经验,有很少的共识,指导我们的理解SDOH在SLE的心理影响。鉴于这一领域的证据缺乏,本次范围审查的目的是系统评估过去20年(2000年1月1日至2021年11月16日)关于SDOH与SLE抑郁症相关性的现有研究文献的数量和特征。我们为PubMed和EMBASE开发了一种搜索策略,其中包括抑郁症和狼疮的关键词。在筛选了2,188篇文章后,我们确定了22篇符合纳入标准的原创文章。在6项未校正估计值的研究中,有2项至少有一项SDOH与抑郁症相关,在16项校正估计值的研究中,有13项与抑郁症相关。结果提供了一致但稀疏的证据表明SDOH与SLE患者的抑郁症相关。此外,SLE中的抑郁流行病学可能与一般人群不同,因此抑郁风险在不同性别和种族/民族之间更为相似。需要更多的工作来确定对SLE患者的抑郁和心理健康影响最大的SDOH,以及如何以及何时进行干预。
Social determinants of health (SDOH) influence inequities in systemic lupus erythematosus (SLE). While these inequities contribute to overall disease experience, there is little consensus guiding our understanding of the psychological implications of SDOH in SLE. Given the paucity of evidence in this area, the aim of this scoping review was to systematically assess the volume and features of available research literature on associations of SDOH with depression in SLE over the past 20 years, from 1 January 2000 to 16 November 2021. We developed a search strategy for PubMed and EMBASE that included keywords for depression and lupus. After screening 2,188 articles, we identified 22 original articles that met our inclusion criteria. At least one SDOH was associated with depression in 2 of the 6 studies with unadjusted estimates and 13 of the 16 studies with adjusted estimates. Results provide consistent but sparse evidence that SDOH are associated with depression in SLE. Additionally, depression epidemiology in SLE may differ from the general population such that depression risk is more similar across genders and racial/ethnic groups. More work is needed to identify the SDOH that have the greatest impact on depression and mental health among SLE patients, as well as how and when to intervene.
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