Natural cell-mediated immunity during viral infections.
Natural cell-mediated immunity during viral infections.
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病毒感染期间的自然细胞介导的免疫。
DOI：
10.1007/978-3-642-68069-4_6
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发表时间：
1981
影响因子：
--
通讯作者：
Welsh,RM
中科院分区：
文献类型：
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作者：
Welsh,RM
病毒感染在受感染的宿主中既能引起特异性反应，也能引起非特异性反应。特异性反应包括产生抗病毒抗体和产生病毒特异性细胞毒T细胞。非特异性反应包括体温升高，干扰素的合成，巨噬细胞和自然杀伤细胞(NK细胞)的激活。虽然这些参数中的大多数已经被研究了几年，但直到最近才提出NK细胞可能在病毒感染的耐药性或病理中起作用的概念(在Welsh1978a中回顾)。这一概念特别耐人寻味，因为NK细胞可能具有调节宿主反应的非特异性和特异性的能力。许多研究人员同意，NK细胞和K淋巴细胞，抗体依赖的细胞介导的细胞毒性(ADCC)的媒介，可能代表相同、重叠或相似的效应细胞群(Ojoand Wigzell1978；Herbermanet al.1979年；Papeet al.1979年；Timonen1979)。
Viral infections elicit both specific and nonspecific responses in infected hosts. The specific responses include the production of antiviral antibody and the generation of virus-specific cytotoxic T cells. The non-specific responses include the elevation of body temperature, the synthesis of interferon, and the activation of macrophages and natural killer (NK) cells. While most of these parameters have been studied for a number of years, only recently has the concept been proposed that NK cells may contribute to the resistance or pathology in viral infections (reviewed inWelsh1978a). This concept is particularly intriguing because NK cells may have the capacity to mediate both nonspecific and specific arms of the host response. Many investigators agree that NK cells and K lymphocytes, mediators of antibody-dependent, cell mediated cytotoxicity (ADCC), may represent identical, overlapping, or similar populations of effector cells (OjoandWigzell1978;Herbermanet al. 1979;Papeet al. 1979;Timonen1979).