Differential functional dysconnectivity of caudate nucleus subdivisions in Parkinson's disease
Differential functional dysconnectivity of caudate nucleus subdivisions in Parkinson's disease
复制标题
帕金森病尾状核细分的差异功能障碍。
DOI：
10.18632/aging.103628
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发表时间：
2020-08-31
期刊：
影响因子：
5.2
通讯作者：
Yang, Qi
中科院分区：
文献类型：
--
作者：
Jia, Xiuqin;Pan, Zhenyu;Yang, Qi
帕金森病 (PD) 患者的病理生理学暗示着尾状多巴胺能功能障碍。尽管如此，尾状核（CN）细分的连接特异性和多巴胺的作用仍知之甚少。在这项研究中，我们收集了 34 名 PD 患者和 26 名年龄和性别匹配的健康老年人 (HE) 的 MRI 和神经心理学数据。静息态功能连接分析显示，与其他 CN 细分相比，HE 中 CN 头部与默认模式网络 (DMN)、CN 身体与额顶网络 (FPN) 以及 CN 尾部与视觉网络的连接更加紧密。停药的帕金森病患者在所有这些细分网络中表现出连通性降低。在接受药物治疗的帕金森病患者中，内侧前额叶皮层的 CN 头部网络的功能连接得到显着改善，而背外侧前额叶皮层的身体网络的功能连接也得到改善。这些改善有助于改善帕金森病患者的动机和认知功能。我们的结果强调了 PD 中这些 CN 细分网络的特定改变和多巴胺调节，这可能有助于深入了解这种疾病的病理生理学和治疗。
Caudate dopaminergic dysfunction is implied in the pathophysiology of patients with Parkinson's disease (PD). Still, connectivity specificities of the caudate nucleus (CN) subdivisions and the effect of dopamine are poorly understood. We collected MRI and neuropsychological data from 34 PD patients and 26 age-and sex-matched healthy elderly individuals (HEs) in this study. Resting-state functional connectivity analysis revealed that compared to the other CN subdivisions, the CN head was more strongly connected to the default mode network (DMN), the CN body to the frontoparietal network (FPN), and the CN tail to the visual network in HEs. PD patients off medication showed reduced connectivity within all these subdivision networks. In PD patients on medication, functional connectivity in the CN head network was significantly improved in the medial prefrontal cortex and in the body network it was improved in the dorsolateral prefrontal cortex. These improvements contributed to ameliorated motivation and cognitive function in PD patients. Our results highlighted the specific alterations and dopamine modulation in these CN subdivision networks in PD, which may provide insight into the pathophysiology and therapeutics of this disease.