COMPARTMENTATION OF GLYCOLYTIC AND GLYCOGENOLYTIC METABOLISM IN VASCULAR SMOOTH-MUSCLE
COMPARTMENTATION OF GLYCOLYTIC AND GLYCOGENOLYTIC METABOLISM IN VASCULAR SMOOTH-MUSCLE
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DOI：
10.1126/science.6658455
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发表时间：
1983-01-01
期刊：
影响因子：
56.9
通讯作者：
PAUL, RJ
中科院分区：
文献类型：
--
作者：
LYNCH, RM;PAUL, RJ
血管平滑肌[来自猪颈动脉]的特点是有氧乳酸产生率高，其变化可能与氧化磷酸化无关。这一发现表明新陈代谢存在细胞质区室。发现外源葡萄糖是未刺激条件下有氧糖酵解的唯一前体。尽管高 K+ 的组织去极化导致内源性糖原大幅减少，但外源性葡萄糖仍然是有氧乳酸产生的唯一前体。碳水化合物代谢在血管平滑肌中划分。
Vascular smooth muscle [from the porcine carotid artery] is characterized by a high rate of aerobic lactate production, which may be altered independently of oxidative phosphorylation. This finding suggested a cytoplasmic compartmentation of metabolism. Exogenous glucose was found to be the sole precursor of aerobic glycolysis under unstimulated conditions. Although tissue depolarization with high K+ resulted in a substantial reduction of endogenous glycogen, exogenous glucose remained the sole precursor of aerobic lactate production. Carbohydrate metabolism is compartmentalized in vascular smooth muscle.