Utilization of different dietary lipid sources at high level in herbivorous grass carp (Ctenopharyngodon idella):: mechanism related to hepatic fatty acid oxidation
Utilization of different dietary lipid sources at high level in herbivorous grass carp (Ctenopharyngodon idella):: mechanism related to hepatic fatty acid oxidation
复制标题
草食性草鱼（Ctenopharyngodon idella）高水平利用不同膳食脂质来源：与肝脏脂肪酸氧化相关的机制
DOI：
10.1111/j.1365-2095.2007.00507.x
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发表时间：
2008-02-01
影响因子：
3.5
通讯作者：
Liu, Y. J.
中科院分区：
文献类型：
--
作者：
Du, Z. Y.;Clouet, P.;Liu, Y. J.
草食性草鱼(Ctenophyngodon Idella)对高脂的利用能力较低，但不同的脂源可能会影响这一能力。为了比较不同脂肪来源和不同脂肪水平对草鱼幼鱼生长的影响，在9种饲料中分别添加猪油、玉米与亚麻籽油混合的植物油和n-3富含高不饱和脂肪酸(HUFA)的鱼油，分别饲喂20、60和100g kg(-1)干饲料，饲喂8周。60和100g kg(-1)鱼油组仔猪采食量减少，生长性能下降，肝脏病理改变和脂质过氧化反应增强。相反，在猪油和植物油组，即使在100g kg(-1)的日粮脂肪水平下，采食量和生长性能也没有下降，尽管组织学观察显示这些组的肝脏病变。100g kg(-1)组大鼠血浆甘油三酯和胆固醇含量均显著升高。在60g kg(-1)饲料脂肪水平下，3个油组的肝脏FAβ氧化能力的比较中，鱼油组的线粒体和过氧化物型FA的氧化能力受到损害。结果证实，草鱼利用高脂饲料的能力相对较低，并且过量摄入HUFA将导致比其他FA更严重的不良反应。
Herbivorous grass carp (Ctenopharyngodon idella) has been reported to exhibit low capacity to utilize high dietary lipid, but different lipid sources might affect this limited capacity. In order to compare the effects of different lipid sources with different lipid levels, juvenile grass carp were fed one of nine diets containing three oils [lard, plant oil mixed by maize and linseed oil, and n-3 high unsaturated fatty acid-enriched (HUFA-enriched) fish oil] at three lipid levels (20, 60 and 100 g kg(-1) dry diet) for 8 weeks. Decreased feed intake, poor growth performance, hepatic pathology and higher blood lipid peroxidation were found in 60 and 100 g kg(-1) fish oil groups. Conversely, in lard and plant oil groups, even at 100 g kg(-1) dietary lipid level, feed intake and growth performance did not decrease, despite histological observation revealed hepatic pathology in these groups. Plasma triglyceride and cholesterol contents increased significantly in all 100 g kg(-1) dietary lipid groups. In the comparison of hepatic FA beta-oxidation among three oil groups at 60 g kg(-1) dietary lipid level, impaired mitochondrial and peroxisomal FA oxidation capacity was observed in fish oil group. The results confirmed the relatively low capacity of grass carp to utilize high dietary lipid, and furthermore excess HUFA intake will result in more serious adverse effects than other FA.