Common and novel transcriptional routes to behavioral maturation in worker and male honey bees.
Common and novel transcriptional routes to behavioral maturation in worker and male honey bees.
复制标题
工蜂和雄性蜜蜂行为成熟的常见和新颖的转录途径。
DOI：
10.1111/j.1601-183x.2011.00750.x
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Robinson,GE
中科院分区：
文献类型：
--
作者：
Zayed,A;Naeger,NL;Rodriguez-Zas,SL;Robinson,GE
工蜂（Apis mellifera）经历了一个行为成熟的过程，导致它们从蜂巢内的任务过渡到觅食，这一过程与大脑中深刻的转录变化有关。在工人行为成熟过程中观察到的大脑基因表达的变化可能代表了劳动分工的衍生程序或与社会无关的一般程序。雄性蜜蜂（雄蜂）经历了一个与交配飞行开始相关的行为成熟过程，但不参与劳动分工。因此，雄蜂为与蜜蜂行为成熟相关的极化转录变化提供了一个很好的参考点。我们分析了成年雄蜂和工蜂的脑转录组，以比较和对比与两性行为成熟相关的差异。行为成熟和性行为都与大脑中数千个基因表达的变化有关。许多参与神经元发育、行为和调节奖赏感知的神经递质的生物合成的基因表现出性别偏倚的基因表达。此外，大多数与行为成熟相关的转录变化在雄蜂和工蜂中是共同的，与共同的遗传和生理调节相一致。我们的研究表明，存在一个共同的行为成熟程序，该程序已被采纳和修改，以产生不同的工蜂和雄蜂的行为和认知表型。
Worker honey bees (Apis mellifera) undergo a process of behavioral maturation leading to their transition from in‐hive tasks to foraging – a process which is associated with profound transcriptional changes in the brain. Changes in brain gene expression observed during worker behavioral maturation could represent either a derived program underlying division of labor or a general program unrelated to sociality. Male bees (drones) undergo a process of behavioral maturation associated with the onset of mating flights, but do not partake in division of labor. Drones thus provide an excellent reference point for polarizing transcriptional changes associated with behavioral maturation in honey bees. We assayed the brain transcriptomes of adult drones and workers to compare and contrast differences associated with behavioral maturation in the two sexes. Both behavioral maturation and sex were associated with changes in expression of thousands of genes in the brain. Many genes involved in neuronal development, behavior, and the biosynthesis of neurotransmitters regulating the perception of reward showed sex‐biased gene expression. Furthermore, most of the transcriptional changes associated with behavioral maturation were common to drones and workers, consistent with common genetic and physiological regulation. Our study suggests that there is a common behavioral maturation program that has been co‐opted and modified to yield the different behavioral and cognitive phenotypes of worker and drone bees.