Updates on Heart Transplantation
Updates on Heart Transplantation
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DOI：
10.1007/s11897-019-00432-3
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发表时间：
2019-10-01
影响因子：
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通讯作者：
Kobashigawa, Jon A.
中科院分区：
文献类型：
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作者：
Shah, Kevin S.;Kittleson, Michelle M.;Kobashigawa, Jon A.
回顾的目的-这篇综述的目的是提供一个全面的最新进展心脏transplantation.Recent Findings心脏移植现在是一个既定的治疗终末期心力衰竭，虽然挑战仍然存在。然而，过去几年的多项进展将提高心脏移植受者的生存率和生活质量。这些进展包括接受以前考虑的边缘供体心脏，供体心脏分配政策的修订，脱敏方案的进展，免疫抑制方案的定制，以及排斥反应和同种异体移植物血管病诊断的改进。充分利用现有器官，完善致敏处理和排斥反应及移植物血管病变的诊断。
Purpose of Review The purpose of this review is to provide a comprehensive update on recent advances in heart transplantation.Recent Findings Heart transplantation is now an established therapy for end-stage heart failure, though challenges still exist. However, multiple advances over the past few years will improve the survival and quality of life of heart transplant recipients. These advances include acceptance of previously considered marginal donor hearts, revisions to the donor heart allocation policy, advances in desensitization regimens, tailoring of immunosuppression regimens, and improvement in the diagnosis of rejection and allograft vasculopathy.Summary Heart transplantation is evolving to provide better quality of life and survival to higher risk recipients with methods to broaden the donor pool, make the best use of existing organs, and refine the management of sensitization and diagnosis of rejection and allograft vasculopathy.