Relationship Between Low Relative Muscle Mass and Coronary Artery Calcification in Healthy Adults
Relationship Between Low Relative Muscle Mass and Coronary Artery Calcification in Healthy Adults
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DOI：
10.1161/atvbaha.116.307156
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发表时间：
2016-05-01
影响因子：
8.7
通讯作者：
Ryu, Seungho
中科院分区：
文献类型：
--
作者：
Ko, Byung-Joon;Chang, Yoosoo;Ryu, Seungho
肌肉减少症或低肌肉质量与心血管危险因素有关;然而，低肌肉质量与亚临床动脉粥样硬化之间的关系在很大程度上尚未研究。我们调查了肌肉质量是否与冠状动脉钙化（CAC）在一个大样本的中年asymptomatic adultes.Approach和Results-We进行了一项横断面研究31108无症状的成年人没有癌症，糖尿病，或已知的心血管疾病谁进行了健康体检，包括心脏断层扫描估计CAC分数在2012年和2013年之间。使用生物电阻抗分析仪估计骨骼肌质量指数（SMI）[SMI（%）=总骨骼肌质量（kg）/体重（kg）x100]。我们使用多变量调整的Tobit模型和多项logistic回归模型评估SMI和CAC评分之间的关系。在31108例受试者中，3374例受试者（10.9%）的CAC评分为1 - 100，628例受试者（2.0%）的CAC评分>100。SMI与CAC评分比率呈负相关。具体而言，在调整潜在混杂因素的多变量调整模型中，与四分位数4相比，四分位数1、2和3的SMI CAC评分比（95%置信区间）分别为2.27（1.70-3.05）、1.46（1.15-1.85）和1.24（0.98-1.55）（趋势P
Objective-Sarcopenia or low muscle mass is related to cardiovascular risk factors; however, the association between low muscle mass and subclinical atherosclerosis has been largely unexplored. We investigated whether muscle mass is related to coronary artery calcification (CAC) in a large sample of middle-aged asymptomatic adults.Approach and Results-We performed a cross-sectional study of 31108 asymptomatic adults without cancer, diabetes mellitus, or known cardiovascular disease who underwent a health checkup examination including cardiac tomography estimation of CAC scores between 2012 and 2013. Skeletal muscle mass index (SMI) [SMI (%)=total skeletal muscle mass (kg)/body weight (kg)x100] was estimated using a bioelectrical impedance analyzer. We assessed the relationship between SMI and CAC scores using both multivariate-adjusted Tobit models and multinomial logistic regression models. Of the 31108 subjects, 3374 subjects (10.9%) had a CAC score 1 to 100, and 628 subjects (2.0%) had a CAC score >100. SMI was inversely associated with CAC score ratios. Specifically, in a multivariable-adjusted model adjusting for potential confounders, CAC score ratios (95% confidence intervals) of SMI for quartiles 1, 2, and 3 compared with quartile 4 were 2.27 (1.70-3.05), 1.46 (1.15-1.85), and 1.24 (0.98-1.55), respectively (P for trend