Functional anatomy of visuomotor skill learning in human subjects examined with positron emission tomography
Functional anatomy of visuomotor skill learning in human subjects examined with positron emission tomography
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DOI：
10.1111/j.1460-9568.1996.tb01249.x
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发表时间：
1996-04-01
影响因子：
3.4
通讯作者：
Evans, AC
中科院分区：
文献类型：
--
作者：
Doyon, J;Owen, AM;Evans, AC
本研究旨在研究在习得过程的早期和后期，与重复视觉运动序列的学习相关的局部脑血流量(CBF)模式。此外，血行的变化与学习这种技能的内隐和外显方面有关。14名正常对照组受试者在执行任务时被扫描：(I)在视觉运动序列的早期和晚期；(Ii)在获得序列的明确知识之后；以及(Iii)在两种控制条件(知觉和随机序列)中，从高度学习的条件中减去随机条件，显示了小脑右侧腹侧纹状体和齿状核的特定区域的活动。右侧大脑半球的血流变化也见于内侧、后顶叶和纹前区域，以及扣带回皮质的前部。最后，一旦受试者获得了在高度学习的条件下呈现的嵌入序列的显性知识，仅在右侧大脑半球的中腹外侧额叶区域观察到CBF活动增加，这些发现证实了纹状体和小脑都参与了视觉运动技能的内隐获得，特别是在学习过程的高级阶段，此外，腹外侧额前皮质优先参与了这一任务的陈述方面。
The present study was designed to examine patterns of regional cerebral blood flow (CBF) associated with the learning of a repeated visuomotor sequence both in the early and late phases of the acquisition process. In addition, changes in blood Row related to the implicit versus explicit aspects of learning such a skill were investigated. Fourteen normal control subjects were scanned while performing the task (i) in both early and advanced]earning stages of the visuomotor sequence; (ii) after having acquired explicit knowledge of the sequences; and (iii) in two control conditions (perceptual and random sequence), Subtraction of the random condition from the highly learned condition revealed specific areas of activity in the right ventral striatum and dentate nucleus of the cerebellum. Blood flow changes in the right hemisphere were also seen in the medial posterior parietal and prestriate regions, as well as in the anterior cingulate cortex. Finally, once the subjects had acquired explicit knowledge of the embedded sequence that was presented in the highly learned condition, increased CBF activity was observed only in the mid-ventrolateral frontal area in the right hemisphere, These findings confirm that both the striatum and the cerebellum are involved in the implicit acquisition of a visuomotor skill, especially in the advanced stages of the learning process, and furthermore that the ventrolateral prefrontal cortex contributes preferentially to the declarative aspect of this task.