Individual differences in resting-state functional connectivity with the executive network: support for a cerebellar role in anxiety vulnerability
Individual differences in resting-state functional connectivity with the executive network: support for a cerebellar role in anxiety vulnerability
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DOI：
10.1007/s00429-015-1088-6
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发表时间：
2016-07-01
影响因子：
3.1
通讯作者：
Servatius, Richard J.
中科院分区：
文献类型：
--
作者：
Caulfield, Meghan D.;Zhu, David C.;Servatius, Richard J.
本研究的特点与执行的内在功能连接网络小脑连接。使用种子区域在右侧和左侧背外侧前额叶皮层（dlPFC）和右眶额，我们测量了健康的大学年龄的参与者的静息态大脑连接。基于先前的研究表明小脑和行为抑制的自我报告措施之间的关系，我们评估了组间连接的个体差异。总的来说，小脑小叶VIII的内在活动与执行网络和小脑脚I与显着网络显着相关。组间比较表明，在行为抑制的个人更强的小脑与执行网络的连接。在Crus I，一个区域先前牵连在非运动小脑功能的内在活动，显着相关的内在活动在右侧dlPFC种子区。这些发现支持了越来越多的研究表明小脑对高级认知过程的影响，将这种关系扩展到焦虑脆弱性的个体差异。
This study characterized cerebellar connectivity with executive intrinsic functional connectivity networks. Using seed regions at the right and left dorsolateral prefrontal cortices (dlPFC) and right orbital frontoinsula, we measured resting-state brain connectivity in healthy college-aged participants. Based on the previous research demonstrating a relationship between the cerebellum and self-report measures of behavioral inhibition, we assessed individual differences in connectivity between groups. Overall, intrinsic activity in cerebellar lobule VIII was significantly correlated with the executive network and cerebellar Crus I with the salience network. Between-group comparisons indicated stronger cerebellar connectivity with the executive network in behaviorally inhibited individuals. Intrinsic activity in Crus I, a region previously implicated in non-motor cerebellar functions, significantly correlated with intrinsic activity in the right dlPFC seed region. These findings support a growing number of studies demonstrating cerebellar influence on higher cognitive processes, extending this relationship to individual differences in anxiety vulnerability.