Influence of the on-line ELF-EMF stimulation on the electrophysiological properties of the rat hippocampal CA1 neurons in vitro.
Influence of the on-line ELF-EMF stimulation on the electrophysiological properties of the rat hippocampal CA1 neurons in vitro.
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DOI：
10.1063/1.5006520
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发表时间：
2017-10
期刊：
影响因子：
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通讯作者：
Yu Zheng;Wei-Ying Ma;Lei Dong;J. Dou;Yang Gao;Jing Xue
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文献类型：
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作者：
Yu Zheng;Wei-Ying Ma;Lei Dong;J. Dou;Yang Gao;Jing Xue
极低频电磁场(ELF-EMF)已被证明对人类健康具有环境负面影响，但其治疗效果对患有神经疾病的患者有利。尽管取得了这一成功，但ELF-EMF的应用已经超出了对其内部机理的理解。最近发现，在线磁刺激可能比离线磁刺激更具优势，并已被证明在体外激活前额叶皮质锥体神经元是有效的。在此，我们对COMSOL模型中的激励线圈进行计算模拟，以描述在线磁场分布的均匀性。有趣的是，模拟数据和实际测量表明，由在线刺激线圈产生的磁通密度相似。该磁刺激器可诱发大鼠海马CA1区神经元钠通道电流和场兴奋性突触后电位，并成功地展示了其在激活神经元组织方面的广泛应用。这些发现进一步提高了在线磁刺激仪器可能成为生物电磁学领域研究的有效替代方案的可能性。
The extremely low frequency electromagnetic fields (ELF-EMFs) have been shown to have an environmentally negative effect on humans' health; however, its treatment effect is beneficial for patients suffering from neurological disorders. Despite this success, the application of ELF-EMF has exceeded in the understanding of its internal mechanism. Recently, it was found that on-line magnetic stimulation may offer advantages over off-line magnetic exposure and has proven to be effective in activating the prefrontal cortex pyramidal neurons in vitro. Here, we perform computational simulations of the stimulation coils in COMSOL modeling to describe the uniformity of the distribution of the on-line magnetic field. Interestingly, the modeling data and actual measurements showed that the densities of the magnetic flux that was generated by the on-line stimulation coils were similar. The on-line magnetic stimulator induced sodium channel currents as well as field excitatory postsynaptic potentials of the rat hippocampal CA1 neurons and successfully demonstrated its extensive applications to activate neuronal tissue. These findings further raise the possibility that the instrument of on-line magnetic stimulation may be an effective alternative for studies in the field of bioelectromagnetics.