Synthesis and characterization of diselenide crosslinked polymeric micelles via Diels–Alder click reaction
Synthesis and characterization of diselenide crosslinked polymeric micelles via Diels–Alder click reaction
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DOI：
10.1080/15421406.2018.1467617
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发表时间：
2018-02
影响因子：
0.7
通讯作者：
S. Salma;C. M. Le;Dong woo Kim;X. Cao;Y. Jeong;K. Lim
中科院分区：
文献类型：
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作者：
S. Salma;C. M. Le;Dong woo Kim;X. Cao;Y. Jeong;K. Lim
ABSTRACT A well-defined amphiphilic block copolymer, poly (ethylene oxide)-b-(poly (furfuryl methacrylate) (PEO-b-PFMA) was prepared by single electron transfer living radical polymerization using tris(dimethylamino)ethyl amine (Me6TREN) as a ligand. The block copolymer formed sub-100 nm micelles in water with PEO as a shell and PFMA as a core. Diels–Alder click type reaction was employed to form core-crosslinked micelles using a diselenide-containing crosslinker without any catalyst. The block copolymer and micelles were characterized by gel permeation chromatography, nuclear magnetic resonance, Fourier-transform infrared spectroscopy, dynamic light scattering analysis and transmission electron microscopy. The stability of core-crosslinked micelles under reductive-oxidative condition was also investigated. The diselenide crosslinked micelles displayed good stability against extensive dilution but decomposed under the presence of hydrogen peroxide or glutathione. The redox responsive core-crosslinked micelles can be a promising carrier for drug delivery applications.
