One-pot synthesis of imidazolines from aldehydes: detailed study about solvents and substrates
One-pot synthesis of imidazolines from aldehydes: detailed study about solvents and substrates
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DOI：
10.1016/j.tet.2006.11.007
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发表时间：
2007-01-15
期刊：
影响因子：
2.1
通讯作者：
Kita, Yasuyuki
中科院分区：
文献类型：
--
作者：
Fujioka, Hiromichi;Murai, Kenichi;Kita, Yasuyuki
以醛和二胺为原料，通过NBS氧化缩醛胺中间体，一锅法合成了咪唑啉。该方法可应用于各种芳香族和脂肪族醛以及N-未取代和N-单取代的1，2-二胺。此外，发现在使用N-未取代的1，2-二胺的反应中，CH 2Cl 2可以改变为TBME，一种更环境友好的溶剂。该反应条件温和，具有化学选择性。(c)2006年由Elsevier Ltd.出版
Imidazolines were prepared in one-pot operation from aldehydes and diamines through oxidation of aminal intermediates by NBS. This method could be applied to various aromatic and aliphatic aldehydes and N-nonsubstituted and N-monosubstituted 1,2-diamines. Furthermore, it was found that CH2Cl2 could be altered to TBME, a more environmentally friendly solvent, in the reaction using N-nonsubstituted 1,2-diamines. The reaction conditions were very mild and chemoselective. (c) 2006 Published by Elsevier Ltd.