Changes in the fracture toughness of bone may not be reflected in its mineral density, porosity, and tensile properties
Changes in the fracture toughness of bone may not be reflected in its mineral density, porosity, and tensile properties
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DOI：
10.1016/s8756-3282(98)00071-4
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发表时间：
1998-07-01
期刊：
影响因子：
4.1
通讯作者：
Agrawal, CM
中科院分区：
文献类型：
--
作者：
Wang, XD;Masilamani, NS;Agrawal, CM
骨骼中与骨骼相关的变化通常会导致骨骼对骨折的敏感性增加。这种变化最有可能发生在骨的成分中，即矿物相和有机相，以及它们的空间排列，表现为取向和微观结构。然而，在过去，骨丢失或骨矿物质密度下降被认为是骨折风险增加的主要因素，弹性模量和极限强度通常用于评估骨质量和强度。然而，这些属性是否提供了足够的信息，骨骨折的可能性仍然存在争议。使用一种新的断裂韧性测试，测量在材料内传播裂纹所需的能量或应力强度，本研究的目的是研究骨的矿物质密度和机械性能是否可以准确预测骨脆性，如断裂韧性所测量的。在狒狒模型中，骨的断裂韧性（K-IC）、骨矿物质密度（BMD）、弹性模量（E）、屈服强度和极限强度（σ（y）和σ（s））、孔隙度（P-o）和显微硬度（H-v）的变化作为年龄的函数进行了检查。随着年龄的增长，骨的断裂韧性降低，显微硬度增加。然而，未发现BMD、E、P-o、sigma（y）和sigma（s）随年龄变化的显著变化。此外，简单回归分析显示，骨断裂韧性与其他参数之间没有显着的相关性，除了骨的显微硬度。本研究的结果表明，骨断裂韧性的变化可能不一定反映在其矿物密度，孔隙率，弹性模量，屈服强度和极限强度。(Bone 23：67-72; 1998）（C）1998由Elsevier Science Inc. All rights reserved.
Age-related changes in the skeleton often lead to an increase in the susceptibility of bone to fracture. Such changes most likely occur in the constituents of bone, namely, the mineral and organic phases, and in their spatial arrangement manifested as orientation and microstructure. In the past, however, bone loss or decline in bone mineral density has been considered to be the major contributing factor for the increased risk of bone fractures, and elastic modulus and ultimate strength have been commonly used to assess bone quality and strength. However, whether these properties provide sufficient information regarding the likelihood of bone to fracture remains debatable. Using a novel fracture toughness test, which measures the energy or stress intensity required to propagate a crack within a material, the objective of this study was to investigate if the mineral density and mechanical properties of bone can accurately predict bone fragility as measured by fracture toughness. Changes in fracture toughness (K-IC), bone mineral density (BMD), elastic modulus (E), yield and ultimate strength (sigma(y) and sigma(s)), porosity (P-o), and microhardness (H-v) of bone were examined as a function of age in a baboon model. With increasing age, the fracture toughness of bone decreased, and its microhardness increased. However, no significant changes were found in BMD, E, P-o, sigma(y), and sigma(s) as a function of age. In addition, simple regression analyses revealed no significant correlation between bone fracture toughness and the other parameters, except for microhardness of bone. The results of this study indicate that changes in bone fracture toughness may not be necessarily reflected in its mineral density, porosity, elastic modulus, yield strength, and ultimate strength. (Bone 23: 67-72; 1998) (C) 1998 by Elsevier Science Inc. All rights reserved.