Sleep deprivation and energy metabolism: to sleep, perchance to eat?
Sleep deprivation and energy metabolism: to sleep, perchance to eat?
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DOI：
10.1097/med.0b013e3282be9093
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发表时间：
2007-10-01
期刊：
影响因子：
--
通讯作者：
Penev, Plamen D
中科院分区：
文献类型：
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作者：
Penev, Plamen D
综述目的：目前许多人每晚只睡5-6小时。流行病学研究表明，自我报告的睡眠不足与肥胖症和糖尿病发病率的增加有关，这突显了这一趋势对公共健康的重要性。这一发现引发了对哺乳动物睡眠和新陈代谢调节机制的新研究。新的发现：在啮齿动物中，饥饿时期伴随着警觉性的提高和睡眠的丧失，这可能是为了帮助最大限度地寻找食物和能量生存，而睡眠剥夺会导致能量消耗增加和体重减轻，这与睡眠在能量保护和组织维护中的作用是一致的。关于人类相应过程的信息是有限的。现有数据表明，尽管存在质和量的差异，人类的睡眠和新陈代谢也存在相互联系。总结：在资源有限的环境中的进化已经在睡眠和能量稳态之间建立了双向联系，其分子机制正在迅速出现。流行病学数据表明，在一个促进身体不活动和暴饮暴食的环境中，人类自愿限制睡眠的独特能力可能会对代谢健康产生负面影响。需要随机干预试验来证实这一假说的有效性。
PURPOSE OF REVIEW: Many people currently sleep only 5-6 h per night. Epidemiological studies have demonstrated that self-reported short sleep is associated with an increased incidence of obesity and diabetes, highlighting the importance of this trend for public health. This finding has triggered renewed research into the mechanisms that link the regulation of mammalian sleep and metabolism.RECENT FINDINGS: In rodents, periods of starvation are accompanied by increased vigilance and sleep loss, presumably to help maximize food finding and energetic survival, whereas sleep deprivation results in increased energy expenditure and weight loss, consistent with a role of sleep in energy conservation and tissue maintenance. Information about the corresponding processes in humans is limited. Available data indicate that despite the presence of qualitative and quantitative differences, human sleep and metabolism also share reciprocal connections.SUMMARY: Evolution in an environment with limited resources has established bidirectional links between sleep and energy homeostasis, the molecular mechanisms of which are emerging rapidly. Epidemiological data suggest that the unique ability of humans to restrict their sleep voluntarily in an environment that promotes physical inactivity and overeating may have a negative impact on metabolic health. Randomized intervention trials are needed to confirm the validity of this hypothesis.