Application of PRF in surgical management of periapical lesions.
Application of PRF in surgical management of periapical lesions.
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DOI：
10.4103/0975-5950.117825
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发表时间：
2013-01
期刊：
影响因子：
--
通讯作者：
Singh R
中科院分区：
文献类型：
--
作者：
Singh S;Singh A;Singh S;Singh R
富含血小板的纤维蛋白广泛用于刺激和加速软组织和骨愈合，因为局部和连续递送生长因子和蛋白质，模拟生理伤口愈合和修复组织过程的需要。本文将介绍第二代血小板浓缩物--富血小板纤维蛋白（PRF）。十五例中，传统的牙髓治疗未能解决问题，根尖周根端手术是必需的。在6个月结束时，所有患者均显示出完全的骨再生。在不存在外源性凝血酶的情况下，通过高速离心产生由完整血小板和纤维蛋白制成的致密、交联、物理上坚固的PRF，产生用于组织修复的理想支架。
Platelet rich fibrin is widely used in stimulation and acceleration of soft tissue and bone healing because of local and continuous delivery of growth factors and proteins, mimicking the needs of the physiological wound healing and reparative tissue processes. This article will serve to introduce a second generation platelet concentrate, platelet-rich fibrin (PRF). Fifteen cases are presented in which conventional endodontic therapy failed to resolve the problem and periapical root-end surgery was required. At the end of six months, all patients showed complete bone regeneration. Production of a dense, cross-linked, physically robust PRF made of intact platelets and fibrin by high-speed centrifugation in the absence of exogenous thrombin, yields an ideal scaffold for use in tissue repair.