EVIDENCE FOR DEGENERATIVE AND REGENERATIVE CHANGES IN NEOSTRIATAL SPINY NEURONS IN HUNTINGTONS-DISEASE
EVIDENCE FOR DEGENERATIVE AND REGENERATIVE CHANGES IN NEOSTRIATAL SPINY NEURONS IN HUNTINGTONS-DISEASE
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DOI：
10.1126/science.3155875
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发表时间：
1985-01-01
期刊：
影响因子：
56.9
通讯作者：
DIFIGLIA, M
中科院分区：
文献类型：
--
作者：
GRAVELAND, GA;WILLIAMS, RS;DIFIGLIA, M
对亨廷顿氏病患者和对照组新纹状体的高尔基体进行了检查。在亨廷顿氏病的所有病例中，中型多刺神经元树突的形态明显改变，表现为末端和附属物的弯曲、棘密度的减少或增加以及棘的大小和形状异常。在中型和大型棘状神经元中很少观察到病理变化。这些发现为亨廷顿病中多刺神经元的同时变性和生长提供了证据，并支持了新纹状体神经元的特定群体选择性参与其发病机制的观点。
Golgi impregnations of neostriatum from decreased Huntington''s disease patients and controls were examined. In all cases of Huntington''s disease the morphology of dendrites of medium-sized spiny neurons was markedly altered by the appearance of recurved endings and appendages, a decrease or increase in the density of spines and abnormalities in the size and shape of spines. Pathological changes were rarely observed in medium-sized and large aspiny neostriatal neurons. The findings provide evidence for simultaneous degeneration and growth of spiny neurons in Huntington''s disease and support the view that a specific population of neostriatal neurons is selectively involved in its pathogenesis.