γ-Tocotrienol metabolism and antiproliferative effect in prostate cancer cells
γ-Tocotrienol metabolism and antiproliferative effect in prostate cancer cells
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DOI：
10.1196/annals.1331.054
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发表时间：
2004-01-01
期刊：
影响因子：
--
通讯作者：
Galli, F
中科院分区：
文献类型：
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作者：
Conte, C;Floridi, A;Galli, F
在这项研究中，我们评估了生育三烯醇(T3)对PC3和LNCaP前列腺癌细胞的抑制增殖作用以及存在一种特定的维生素E代谢。这些细胞系能够转化生育酚(T)和相应的羧乙基-羟色胺代谢物(CEHC)中的T3。这种新陈代谢的程度和对细胞生长的抑制作用遵循数量级α-T
In this study, we evaluated the antiproliferative effect of tocotrienols (T3) and the presence of a specific vitamin E metabolism in PC3 and LNCaP prostate cancer cells. These cell lines are able to transform tocopherols (T) and T3 in the corresponding carboxyethyl-hydroxychromans metabolites (CEHCs). The extent of this metabolism and the inhibitory effect on cell growth followed the order of magnitude alpha-T