CORRELATION OF COORDINATED AMINO-ACID SUBSTITUTIONS WITH FUNCTION IN VIRUSES RELATED TO TOBACCO MOSAIC-VIRUS
CORRELATION OF COORDINATED AMINO-ACID SUBSTITUTIONS WITH FUNCTION IN VIRUSES RELATED TO TOBACCO MOSAIC-VIRUS
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DOI：
10.1016/0022-2836(87)90352-4
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发表时间：
1987-02-20
影响因子：
5.6
通讯作者：
KLUG, A
中科院分区：
文献类型：
--
作者：
ALTSCHUH, D;LESK, AM;KLUG, A
有7种烟叶病毒外壳蛋白的序列数据，同源性至少在26%到82%之间，已知烟草花叶病毒（TMV）的原子坐标。具有相同氨基酸取代模式的残基组之间存在显著的空间关系。这有力地表明，它们的位置与一种特定的功能有关，至少在这些残基与野生型相同的病毒中是这样。TMV最保守的特征是RNA结合区。核心残基在所有病毒中都是保守的，或者在体积上表现出互补的突变。亚基间接触的特异性在三种亲缘关系较远的病毒中以不同的方式实现。
Sequence data are available for the coat proteins of seven tobamoviruses, with homologies ranging from at least 26% to 82%, and atomic co-ordinates are known for tobacco mosaic virus (TMV) vulgare. A significant spatial relationship has been found between groups of residues with identical amino acid substitution patterns. This strongly suggests that their location is linked to a particular function, at least in viruses identical with the wild-type for these residues. The most conserved feature of TMV is the RNA binding region. Core residues are conserved in all viruses or show mutations complementary in volume. The specificity of inter-subunit contacts is achieved in different ways in the three more distantly related viruses.