REINFORCING PROPERTIES OF EJACULATION IN THE MALE-RAT - ROLE OF OPIOIDS AND DOPAMINE
REINFORCING PROPERTIES OF EJACULATION IN THE MALE-RAT - ROLE OF OPIOIDS AND DOPAMINE
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DOI：
10.1037/0735-7044.104.1.177
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发表时间：
1990-02-01
影响因子：
1.9
通讯作者：
BERENFELD, R
中科院分区：
文献类型：
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作者：
AGMO, A;BERENFELD, R
用条件性位置偏爱范式评价雄性大鼠射精后的奖赏效应。据推测，射精会导致一种奖赏状态，因此它可以对环境刺激产生条件反射。雄性被允许射精一次，然后立即被转移到一个偏爱地点的笼子里。一次射精产生了场所偏好。纳洛酮(16 mg/kg)不仅阻断了这种位置偏爱，而且还引起了位置厌恶。纳洛酮本身对位置偏好没有影响。这表明，内源性阿片类物质的释放使射精获得回报。吡莫齐特1 mg/kg对射精奖赏无影响。因此，多巴胺似乎对交配的效果并不重要。也许强迫性行为与阿片成瘾者的强迫性药物使用遵循相同的机制。
Ejaculation-induced reward in the male rat was evaluated by the conditioned place-preference paradigm. It was supposed that ejaculation induces a reward state such that it can be conditioned to environmental stimuli. Males were allowed to ejaculate once and were then immediately transferred to a place-preference cage. One ejaculation produced place preference. Naloxone (16 mg/kg) not only blocked this place preference but also induced a place aversion. Naloxone by itself had no effect on place preference. It is suggested that release of endogenous opioids renders ejaculation rewarding. Pimozide, in a dose of 1 mg/kg, had no effect on ejaculation-induced reward. Dopamine thus seems to be of slight importance for that effect of copulation. Perhaps compulsive sexual activity obeys the same mechanisms as compulsive drug use in opiate addicts.