Transgenerational programming of maternal behaviour by prenatal stress.
Transgenerational programming of maternal behaviour by prenatal stress.
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DOI：
10.1186/1471-2393-13-s1-s9
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发表时间：
2013
影响因子：
3.1
通讯作者：
Metz GA
中科院分区：
文献类型：
--
作者：
Ward ID;Zucchi FC;Robbins JC;Falkenberg EA;Olson DM;Benzies K;Metz GA
围产期事件有可能对后代和可能的后代的生理和行为规划产生巨大影响。在这里，我们的特点是跨代的变化，大鼠母体行为的功能，妊娠和产前压力。将亲代妊娠母鼠在第12-18天（F0-S）暴露于应激。他们的女儿和孙女是应激的（F1-SS，F2-SSS）或非应激的（F1-SN，F2-SNN）。在妊娠母鼠通常表现出高频率的追尾行为时，分析母体产前行为。与对照组相比，F1-SS、F2-SNN和F2-SSS组的追尾行为显著减少。多代压力（SSS）的影响略超过了跨代压力（SNN），并导致没有尾巴追逐行为。这些发现表明，大鼠的产前母性行为是由压力反应的跨代遗传来编程的。因此，产前母亲行为的改变可能是妊娠期间应激反应激活的指标。
Peripartum events hold the potential to have dramatic effects in the programming of physiology and behaviour of offspring and possibly subsequent generations. Here we have characterized transgenerational changes in rat maternal behaviour as a function of gestational and prenatal stress. Pregnant dams of the parental generation were exposed to stress from days 12-18 (F0-S). Their daughters and grand-daughters were either stressed (F1-SS, F2-SSS) or non-stressed (F1-SN, F2-SNN). Maternal antepartum behaviours were analyzed at a time when pregnant dams usually show a high frequency of tail chasing behaviours. F1-SS, F2-SNN and F2-SSS groups showed a significant reduction in tail chasing behaviours when compared with controls. The effects of multigenerational stress (SSS) slightly exceeded those of transgenerational stress (SNN) and resulted in absence of tail chasing behaviour. These findings suggest that antepartum maternal behaviour in rats is programmed by transgenerational inheritance of stress responses. Thus, altered antepartum maternal behaviour may serve as an indicator of an activated stress response during gestation.