Functional Evidence for a Cerebellar Node of the Dorsal Attention Network
Functional Evidence for a Cerebellar Node of the Dorsal Attention Network
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DOI：
10.1523/jneurosci.0344-16.2016
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发表时间：
2016-06-01
影响因子：
5.3
通讯作者：
Somers, David C.
中科院分区：
文献类型：
--
作者：
Brissenden, James A.;Levin, Emily J.;Somers, David C.
“背部注意网络”或“额顶网络”指的是支持持续注意力和工作记忆的大脑皮层区域网络。最近的工作表明，背侧注意网络的皮质节点与小脑腹侧VII/VIII小叶附近的一个区域具有内在的功能联系。在这里，我们进行了一系列基于任务和静息状态的fMRI实验，以探讨人类小脑参与背侧注意网络的情况。我们观察到，除了典型的皮层背侧注意网络区域外，视觉工作记忆和视觉注意任务还强烈地招募小脑小叶VIIb和VIIIa。在整个小脑中，静息状态与皮质背侧注意网络的功能连接强烈地预测了注意力和工作记忆任务产生的激活水平。关键的是，与背侧注意网络联系最紧密的小脑体素选择性地表现出负荷依赖的活动，这是支持视觉工作记忆的神经结构的一个标志。最后，我们检查了小脑小叶VIIb/VIIIa的任务反应部分和皮质之间的内在功能连接。小脑到皮质的功能连接强烈地预测了任务执行过程中大脑皮层的激活模式。此外，静息状态连接模式显示，小脑小叶VIIb/VIIIa组具有背侧注意网络的皮质节点。这一证据使我们得出结论，背侧注意网络的概念应该扩大到包括小脑小叶VIIb/VIIIa。
The "dorsal attention network" or "frontoparietal network" refers to a network of cortical regions that support sustained attention and working memory. Recent work has demonstrated that cortical nodes of the dorsal attention network possess intrinsic functional connections with a region in ventral cerebellum, in the vicinity of lobules VII/VIII. Here, we performed a series of task-based and resting-state fMRI experiments to investigate cerebellar participation in the dorsal attention network in humans. We observed that visual working memory and visual attention tasks robustly recruit cerebellar lobules VIIb and VIIIa, in addition to canonical cortical dorsal attention network regions. Across the cerebellum, resting-state functional connectivity with the cortical dorsal attention network strongly predicted the level of activation produced by attention and working memory tasks. Critically, cerebellar voxels that were most strongly connected with the dorsal attention network selectively exhibited load-dependent activity, a hallmark of the neural structures that support visual working memory. Finally, we examined intrinsic functional connectivity between task-responsive portions of cerebellar lobules VIIb/VIIIa and cortex. Cerebellum-to-cortex functional connectivity strongly predicted the pattern of cortical activation during task performance. Moreover, resting-state connectivity patterns revealed that cerebellar lobules VIIb/VIIIa group with cortical nodes of the dorsal attention network. This evidence leads us to conclude that the conceptualization of the dorsal attention network should be expanded to include cerebellar lobules VIIb/VIIIa.