10-Year Overview of the Hospital-Based Prevalence and Treatment of Congenital Cataracts: The CCPMOH Experience.
10-Year Overview of the Hospital-Based Prevalence and Treatment of Congenital Cataracts: The CCPMOH Experience.
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DOI：
10.1371/journal.pone.0142298
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Liu Y
中科院分区：
文献类型：
--
作者：
Lin D;Chen J;Lin Z;Li X;Wu X;Long E;Luo L;Zhang B;Chen H;Chen W;Zhang L;Lin H;Chen W;Liu Y
回顾中山眼科中心（ZOC）6年的住院病历，发现先天性白内障（CC）占所有白内障住院病例的2.39%，并且在2010年12月中国卫生部（CCPMOH）儿童白内障项目（CCPMOH）成立之前，手术年龄正在下降。我们的目的是调查CCPMOH成立后4年（2011年1月至2014年12月）的数据，并与之前研究期间（2005年1月至2010年12月）的数据进行比较和组合，以生成10年的CC医院患病率和治疗概述。在CCPMOH成立后的4年里，CC的患病率在所有住院患者中为2.01%，在所有白内障住院患者中为2.78%。大部分符合条件的CC住院患者（71%）居住在中国南方。男孩与女孩的比例为1.42：1。近2/3的患者接受了白内障摘除并一期人工透镜（IOL）植入术，平均年龄为78.40±51.45个月，其余1/3的患者接受了白内障摘除手术，未植入人工晶状体（IOL），平均年龄为10.03±15.92个月。在CCPMOH成立后，发现CC的发病率增加，并且CC住院患者比以前的患者更年轻。10年回顾（206630例住院患者中有2421例CC住院患者）显示CC的数量和患病率呈上升趋势，手术年龄进一步降低。总之，CCPMOH成立后4年的数据和10年的回顾显示，CC病例的医院患病率呈上升趋势，手术年龄进一步降低，这可能反映了CCPMOH成立的影响，并为进一步的CC研究提供了有用的信息，为预防和治疗这种儿童失明的原因提供了有价值的基础。
A review of 6 years of hospitalization charts from Zhongshan Ophthalmic Center (ZOC) revealed that congenital cataracts (CC) accounted for 2.39% of all cataract in-patient cases and that the age at surgery was decreasing before the establishment of the Childhood Cataract Program of the Chinese Ministry of Health (CCPMOH) in December 2010. We aimed to investigate data from the 4 years (January 2011 to December 2014) following the establishment of the CCPMOH, compared, and combined with data from the previous study period (January 2005 to December 2010) to generate a 10-year overview of the hospital-based prevalence and treatment of CC. In the 4-year period after CCPMOH establishment, the prevalence of CC was 2.01% in all hospitalizations, and was 2.78% in all cataract in-patients. Most of the eligible CC in-patients (71%) lived in south China. The ratio of boys to girls was 1.42:1. Nearly 2/3 of the patients underwent cataract extraction with primary intraocular lens (IOL) implantation at a mean age of 78.40±51.45 months, and cataract extraction surgeries without IOL implantation were performed in the remaining 1/3 of patients at a mean age of 10.03±15.92 months. After CCPMOH establishment, an increased incidence of CC was revealed, and the CC in-patients were younger than the patients in the previous period. The 10-year overview (2421 CC in-patients from 206630 hospitalizations) revealed upward trends in both the number and the prevalence of CC and a further reduction in age at surgery. In conclusion, the data from 4-year period after CCPMOH establishment and the 10-year overview showed upward trends in the hospital-based prevalence of CC cases and a further reduction in age at surgery, likely reflecting the effects of the CCPMOH establishment and providing useful information for further CC studies and a valuable foundation for the prevention and treatment of this cause of childhood blindness.