Notch pathway is involved in high glucose-induced apoptosis in podocytes via Bcl-2 and p53 pathways
Notch pathway is involved in high glucose-induced apoptosis in podocytes via Bcl-2 and p53 pathways
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DOI：
10.1002/jcb.24442
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发表时间：
2013-05-01
影响因子：
4
通讯作者：
Duan, Huijun
中科院分区：
文献类型：
--
作者：
Gao, Feng;Yao, Min;Duan, Huijun
近年来的研究表明，Notch通路在糖尿病肾病（DN）的发病机制中起着重要作用，但其确切机制尚不清楚。我们发现高糖诱导足细胞Notch通路表达上调，并伴有Bcl-2和p53通路的改变，从而导致足细胞凋亡。通过化学抑制剂或特异性短发夹RNA（shRNA）载体抑制足细胞中的Notch通路可防止Bcl-2和p53依赖的细胞凋亡。提示Notch通路通过Bcl-2和p53通路介导HG诱导的足细胞凋亡。J.细胞。114：10291038，2013。(c)2012 Wiley Periodicals，Inc.
Recent studies have shown that Notch pathway plays a key role in the pathogenesis of diabetic nephropathy (DN), however, the exact mechanisms remain elusive. Here we demonstrated that high glucose (HG) upregulated Notch pathway in podocytes accompanied with the alteration of Bcl-2 and p53 pathways, subsequently leading to podocytes apoptosis. Inhibition of Notch pathway by chemical inhibitor or specific short hairpin RNA (shRNA) vector in podocytes prevented Bcl-2- and p53-dependent cell apoptosis. These findings suggest that Notch pathway mediates HG-induced podocytes apoptosis via Bcl-2 and p53 pathways. J. Cell. Biochem. 114: 10291038, 2013. (c) 2012 Wiley Periodicals, Inc.