Antisolvent Crystallization of Telmisartan Using Stainless-Steel Micromixing Membrane Contactors.
Antisolvent Crystallization of Telmisartan Using Stainless-Steel Micromixing Membrane Contactors.
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DOI：
10.1021/acs.cgd.3c00123
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发表时间：
2023-05-03
影响因子：
3.8
通讯作者：
Dragosavac, Marijana M.
中科院分区：
文献类型：
--
作者：
Bennett, Matthew John;Beveniou, Elina;Kerr, Alex Robin;Dragosavac, Marijana M.
使用膜微混合接触器，通过在去离子水中的反溶剂结晶，从TEL/DMSO溶液中对活性药物成分（API）替米沙坦（TEL）进行了受控连续结晶。本工作的目的是在搅拌池（批次，LDC-1）和错流（连续，AXF-1）系统中测试具有间隔200 μm的有序10 μm孔的不锈钢膜的TEL形成。通过控制API和溶剂通过膜孔的进料流速以及反溶剂流，可以严格控制微观混合，并由此控制晶体成核和生长。没有膜的分批结晶导致不均匀的结晶过程，得到结晶和无定形TEL材料的混合物。用较高的DMSO含量（4：1 DMSO/DI水）控制结晶速率，导致TEL材料的较慢结晶。当使用去离子水时，两种膜设置（搅拌批料和错流）产生无定形TEL颗粒，而当使用DI水和DMSO的混合物时产生结晶材料。使用膜微混合接触器，通过在去离子水中的反溶剂结晶，从TEL/DMSO溶液中进行了API替米沙坦（TEL）的受控连续结晶。本工作的目的是在搅拌槽（批次，LDC-1）和错流（连续，AXF-1）系统中测试具有有序10 μm孔且孔间距为200 μm的不锈钢膜的TEL形成。通过控制API和溶剂通过膜孔的进料流速以及反溶剂流，可以严格控制微观混合，并由此控制晶体成核和生长。没有膜的分批结晶导致不均匀的结晶过程，得到结晶和无定形TEL材料的混合物。用较高的DMSO含量（4：1 DMSO/DI水）控制结晶速率，导致TEL材料的结晶较慢。当使用去离子水时，两种膜设置（搅拌批料和错流）产生无定形TEL颗粒，而当使用DI水和DMSO的混合物时产生结晶材料。
Controlled continuous crystallization of the active pharmaceutical ingredient (API) telmisartan (TEL) has been conducted from TEL/DMSO solutions by antisolvent crystallization in deionized water using membrane micromixing contactors. The purpose of this work was to test stainless-steel membranes with ordered 10 μm pores spaced at 200 μm in a stirred-cell (batch, LDC-1) and crossflow (continuous, AXF-1) system for TEL formation. By controlling the feed flow rate of the API and solvent, through the membrane pores as well as the antisolvent flow, it was possible to tightly control the micromixing and with that to control the crystal nucleation and growth. Batch crystallization without the membrane resulted in an inhomogeneous crystallization process, giving a mixture of crystalline and amorphous TEL materials. The rate of crystallization was controlled with a higher DMSO content (4:1 DMSO/DI water), resulting in slower crystallization of the TEL material. Both membrane setups, stirred batch and the crossflow, yielded the amorphous TEL particles when deionized water was used, while a crystalline material was produced when a mixture of DI water and DMSO was used. Controlled continuous crystallization of the API telmisartan (TEL) has been conducted from TEL/DMSO solutions by antisolvent crystallization in deionized water using membrane micromixing contactors. The purpose of this work was to test stainless-steel membranes with ordered 10 μm pores spaced at 200 μm in a stirred cell (batch, LDC-1) and crossflow (continuous, AXF-1) system for TEL formation. By controlling the feed flow rate, of the API and solvent, through the membrane pores as well as the antisolvent flow, it was possible to tightly control the micromixing and with that control the crystal nucleation and growth. Batch crystallization without the membrane resulted in an inhomogeneous crystallization process giving a mixture of crystalline and amorphous TEL material. The rate of crystallization was controlled with a higher DMSO content (4:1 DMSO/DI water) resulting in slower crystallization of the TEL material. Both membrane setups, stirred batch and the crossflow, yielded the amorphous TEL particles when deionized water was used, while the crystalline material was produced when a mixture of DI water and DMSO was used.
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DOI：
10.1016/j.apsb.2021.05.014
发表时间：
2021-08
期刊：
Acta pharmaceutica Sinica. B
影响因子：
--
作者：
Bhujbal SV;Mitra B;Jain U;Gong Y;Agrawal A;Karki S;Taylor LS;Kumar S;Tony Zhou Q
通讯作者：
Tony Zhou Q
DOI：
10.1016/j.ejpb.2012.09.019
发表时间：
2013-01-01
影响因子：
4.9
作者：
Lepek, P.;Sawicki, W.;Guzik, L.
通讯作者：
Guzik, L.
影响因子：
3.7
作者：
Hancock, BC;Parks, M
通讯作者：
Parks, M
影响因子：
2.7
作者：
Dina, R;Jafari, M
通讯作者：
Jafari, M
影响因子：
6.6
作者：
Drioli, Enrico;Di Profio, Gianluca;Curcio, Efrem
通讯作者：
Curcio, Efrem