Substance use associated with short sleep duration in patients with schizophrenia or schizoaffective disorder.
Substance use associated with short sleep duration in patients with schizophrenia or schizoaffective disorder.
复制标题
精神分裂症或分裂情感障碍患者的药物使用与睡眠时间短有关。
DOI：
10.1002/ajmg.b.32374
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
Pato,CarlosN
中科院分区：
文献类型：
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作者：
Tang,VivianK;Pato,MicheleT;Sobell,JanetL;Hammond,TereseC;Valdez,MarkM;Lane,ChristianneJ;GenomicPsychiatryCohortConsortium;Pato,CarlosN
研究目的探讨精神分裂症或抑郁型情感性精神障碍（SADD）患者的物质使用与睡眠时间短的关系。设计横断面回顾性研究。研究地点为美国的城市、郊区和农村中心。研究对象为2，462名同意的精神分裂症或抑郁型情感性精神障碍（SADD）成年患者。参与者包括急性或慢性护理环境中的住院患者以及社区住宅中的门诊患者和居民。MeasurementsSubstance use采用了10个问题进行评估，这些问题来自经过充分验证的措施（例如，CAGE问卷）的酒精，大麻和非法药物。短睡眠时间被定义为<6小时的自我报告的睡眠per night.ResultsClose到100%的样本使用尼古丁，而83%的使用尼古丁以外的物质。更重要的是，物质使用和睡眠时间短之间存在显着关联。有趣的是，这种关联是最强的非裔美国人与精神分裂症或SADD.ConclusionsBecause精神科药物往往针对化学受体参与睡眠和物质的使用，了解睡眠时间短，物质的使用在个人与精神分裂症和SADD之间的关联是很重要的。鉴于大多数精神病患者的过早死亡是由于与可改变的风险因素相关的医疗条件，应进行前瞻性研究，以检查短睡眠时间对物质使用等行为的影响。最后，在未来的研究中分析遗传和环境数据可能有助于阐明在患有精神分裂症和SADD的非洲裔美国人中发现的短睡眠时间和物质使用之间的强烈关联。© 2015威利期刊公司.
Study ObjectivesTo examine the association between substance use and short sleep duration in individuals with schizophrenia or schizoaffective disorder, depressive type (SADD).DesignCross‐sectional, retrospective study.SettingUrban, suburban, and rural centers across the United States.Participants2,462 consented, adult individuals with schizophrenia or schizoaffective disorder, depressive type (SADD). Participants included inpatients in acute or chronic care settings as well as outpatients and residents in community dwellings.MeasurementsSubstance use was assessed with 10 questions adopted from well‐validated measures (e.g., CAGE questionnaire) for alcohol, marijuana, and illicit drugs. Short sleep duration was defined as <6 hr of self‐reported sleep per night.ResultsClose to 100% of our sample used nicotine while 83% used substances other than nicotine. More importantly, there was a significant association between substance use and short sleep duration. Interestingly, this association was strongest among African–Americans with schizophrenia or SADD.ConclusionsBecause psychiatric medications often target chemical receptors involved with both sleep and substance use, understanding the association between short sleep duration and substance use in individuals with schizophrenia and SADD is important. Given that the majority of premature deaths in individuals with psychotic illness are due to medical conditions associated with modifiable risk factors, prospective studies designed to examine the effect of short sleep duration on behaviors like substance use should be undertaken. Finally, analyzing genetic and environmental data in a future study might help illuminate the strong association found between short sleep duration and substance use in African–Americans with schizophrenia and SADD. © 2015 Wiley Periodicals, Inc.