A Computer Simulation Study of Anatomy Induced Drift of Spiral Waves in the Human Atrium.
A Computer Simulation Study of Anatomy Induced Drift of Spiral Waves in the Human Atrium.
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DOI：
10.1155/2015/731386
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发表时间：
2015
影响因子：
--
通讯作者：
Biktashev VN
中科院分区：
文献类型：
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作者：
Kharche SR;Biktasheva IV;Seemann G;Zhang H;Biktashev VN
螺旋波与心房解剖结构的相互作用尚不清楚。该模拟研究分离了心房解剖结构对人类心房中螺旋波自发漂移的作用。我们实现了现实和理想化的三维人体心房模型，以研究解剖结构对螺旋波长期（1040 s）行为的功能影响。螺旋波的漂移通过追踪其尖端轨迹来量化，这与心房解剖特征相关。研究了螺旋波与以下理想几何形状的相互作用：（a）具有连续变化的心房壁厚度的楔形结构;（B）具有心房壁厚度突然变化的脊状结构;（c）由连接到心房壁的桥组成的多个桥状结构。螺旋波由厚区向薄区漂移，并沿沿着脊状结构漂移。梳状肌（PM）桥引起的突破模式也被观察到，虽然不常见。观察到靠近PM-心房壁连接处的明显锚定。这些观察结果在现实和理想化模型中是相似的。我们的结论是空间改变心房壁厚度是一个重要的原因漂移的螺旋波。PM桥导致突破模式和诱导螺旋波的瞬态锚定。
The interaction of spiral waves of excitation with atrial anatomy remains unclear. This simulation study isolates the role of atrial anatomical structures on spiral wave spontaneous drift in the human atrium. We implemented realistic and idealised 3D human atria models to investigate the functional impact of anatomical structures on the long-term (∼40 s) behaviour of spiral waves. The drift of a spiral wave was quantified by tracing its tip trajectory, which was correlated to atrial anatomical features. The interaction of spiral waves with the following idealised geometries was investigated: (a) a wedge-like structure with a continuously varying atrial wall thickness; (b) a ridge-like structure with a sudden change in atrial wall thickness; (c) multiple bridge-like structures consisting of a bridge connected to the atrial wall. Spiral waves drifted from thicker to thinner regions and along ridge-like structures. Breakthrough patterns caused by pectinate muscles (PM) bridges were also observed, albeit infrequently. Apparent anchoring close to PM-atrial wall junctions was observed. These observations were similar in both the realistic and the idealised models. We conclude that spatially altering atrial wall thickness is a significant cause of drift of spiral waves. PM bridges cause breakthrough patterns and induce transient anchoring of spiral waves.