Isoforms, structures, and functions of versatile spectraplakin MACF1.
Isoforms, structures, and functions of versatile spectraplakin MACF1.
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多功能 Spectraplakin MACF1 的亚型、结构和功能
DOI：
10.5483/bmbrep.2016.49.1.185
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发表时间：
2016-01
期刊：
影响因子：
3.8
通讯作者：
Qian A
中科院分区：
文献类型：
--
作者：
Hu L;Su P;Li R;Yin C;Zhang Y;Shang P;Yang T;Qian A
Spectraplakins是至关重要的通信，连接细胞骨架组件彼此和细胞连接。微管肌动蛋白交联因子1（Microtubule actin crosslinking factor 1，MACF 1），又称肌动蛋白交联家族7（actin crosslinking family 7，ACF 7），是spectraplakin家族的成员。它作为一种广泛研究的斑点蛋白在许多组织和细胞中表达。MACF 1具有几种具有独特结构和众所周知的功能的同种型，能够交联F-肌动蛋白和微管。MACF 1是一种多功能的斑点蛋白，在细胞过程、胚胎发育、组织特异性功能和人类疾病中具有多种功能。近年来，MACF 1的重要性变得更加明显。在这里，我们总结了目前对MACF 1的存在和功能的认识，并根据我们的研究和其他人对MACF 1的未来研究提供了展望。[BMB报告2016; 49（1）：37-44]
Spectraplakins are crucially important communicators, linking cytoskeletal components to each other and cellular junctions. Microtubule actin crosslinking factor 1 (MACF1), also known as actin crosslinking family 7 (ACF7), is a member of the spectraplakin family. It is expressed in numerous tissues and cells as one extensively studied spectraplakin. MACF1 has several isoforms with unique structures and well-known function to be able to crosslink F-actin and microtubules. MACF1 is one versatile spectraplakin with various functions in cell processes, embryo development, tissue-specific functions, and human diseases. The importance of MACF1 has become more apparent in recent years. Here, we summarize the current knowledge on the presence and function of MACF1 and provide perspectives on future research of MACF1 based on our studies and others. [BMB Reports 2016; 49(1): 37-44]