IMMUNOLOGICAL AND CHEMICAL CORRELATION BETWEEN α‐FETOPROTEINS FROM HUMAN AND SEVERAL MAMMALIAN SPECIES
IMMUNOLOGICAL AND CHEMICAL CORRELATION BETWEEN α‐FETOPROTEINS FROM HUMAN AND SEVERAL MAMMALIAN SPECIES
复制标题
人类和几种哺乳动物的 α-胎蛋白之间的免疫学和化学相关性
DOI：
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发表时间：
1975
影响因子：
5.2
通讯作者：
H. Hirai
中科院分区：
文献类型：
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作者：
S. Nishi;H. Watabe;H. Hirai
对几种动物的甲胎蛋白进行了纯化，比较了它们的相对分子质量、氨基酸组成和肽谱，证明了它们之间的相似之处。这些数据表明，哺乳动物的甲胎蛋白具有密切的抗原性和化学结构。用人甲胎蛋白免疫兔和马，观察到动物不仅与人甲胎蛋白产生抗体反应，而且与其同源甲胎蛋白产生抗体反应。这些结果被解释为对自己甲胎蛋白耐受性的崩溃。
Alpha-Fetoproteins of several animals were purified and their molecular weights, amino acid compositions and peptide maps were compared, demonstrating the close similarities. These data indicated that the alpha-fetoproteins of mammalian species have closely related antigenical and chemical structures. Rabbits and horses were immunized with human alpha-fetoprotein, and it was observed that the animals produced antibodies reaction not only with human alpha-fetoprotein but with their homologous alpha-fetoproteins. The results were interpreted as the breakdown of the tolerance to their own alpha-fetoprotein.