Overexpression of membranal SLC3A2 regulates the proliferation of oral squamous cancer cells and affects the prognosis of oral cancer patients
Overexpression of membranal SLC3A2 regulates the proliferation of oral squamous cancer cells and affects the prognosis of oral cancer patients
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DOI：
10.1111/jop.13132
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发表时间：
2021-01-05
影响因子：
3.3
通讯作者：
Sun, Zhida
中科院分区：
文献类型：
--
作者：
Liang, Jiayu;Sun, Zhida
目的口腔鳞状细胞癌（Oral squamous cell carcinoma，OSCC）是口腔颌面部最常见的恶性肿瘤。本研究旨在探讨SLC3A2在口腔鳞癌组织中的表达及其在口腔鳞癌发生发展中的调控作用。结果SLC3A2基因在口腔鳞癌中的表达高于正常口腔黏膜上皮细胞。SLC3A2在口腔鳞癌组织中的表达水平高于癌旁正常组织。SLC3A2的上调与OSCC患者的晚期和低生存率相关。结论SLC3A2基因敲低可使口腔鳞癌细胞的迁移、侵袭、增殖能力降低，凋亡增加。
Objective Oral squamous cell carcinoma (OSCC) is the most common cancer in oral and maxillofacial tissue. This study aimed to investigate the expression of SLC3A2 in human OSCC tissues and its regulatory roles in OSCC.Methods The expression of SLC3A2 in human OSCC tissues was assessed using immunohistochemistry. The proliferation, migration, and invasion of oral squamous cells were evaluated after knockdown of SLC3A2.Results The expression of SLC3A2 in OSCC was higher than that in normal oral epithelial cells. SLC3A2 had higher expression levels in OSCC tissues than that in adjacent normal tissues. Upregulation of SLC3A2 was associated with advanced stages and poor survival of OSCC patients. In vitro experiments showed that knocking down of SLC3A2 was associated with reduced migration, invasion, and proliferation, but increased apoptosis of OSCC cells.Conclusion SLC3A2 exerted a harmful effect on OSCC patients by increasing migration, invasion and proliferation, and decreasing apoptosis.