Treadmill exercise elevates striatal dopamine D2 receptor binding potential in patients with early Parkinson's disease
Treadmill exercise elevates striatal dopamine D2 receptor binding potential in patients with early Parkinson's disease
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DOI：
10.1097/wnr.0b013e328361dc13
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发表时间：
2013-07-10
期刊：
影响因子：
1.7
通讯作者：
Petzinger, Giselle M.
中科院分区：
文献类型：
--
作者：
Fisher, Beth E.;Li, Quanzheng;Petzinger, Giselle M.
我们之前已经证明了1-甲基-4-苯基-1,2,3,6-四氢吡啶损伤的帕金森病（PD）小鼠模型在剧烈运动后多巴胺能神经传递的变化，包括多巴胺D-2受体（DA-D2R）的增加，使用放射配体[F-18]fallypride的无侵入性PET成像。这项可行性和转化性研究的目的是通过PET成像[F-18] fypride检查高强度运动是否会导致早期PD患者DA-D2R表达的类似改变。在这项初步研究中，4名早期PD患者被随机分为两组，一组接受高强度运动（跑步机训练，每周3次，持续8周），另一组不进行运动。两名年龄相仿的健康个体参加了跑步机训练。使用PET成像技术（[F-18]fallypride）确定DA-D2R结合电位（BP）作为受体表达标记物的改变。将PD患者的翻身表现作为运动前和运动后姿势控制和统一帕金森病评定量表评分的衡量标准进行测定。我们的数据显示，运动诱导的[F-18]假血压升高，以及运动后PD患者姿势控制的改善。未运动的PD患者未观察到DA-D2R血压变化。这些结果表明，运动可以导致多巴胺能信号的神经可塑性，并有助于改善早期PD中可能是任务特异性的功能（姿势控制）。(C) 2013 Wolters Kluwer Health垂直条Lippincott Williams & Wilkins。
We have previously demonstrated changes in dopaminergic neurotransmission after intensive exercise in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of Parkinson's disease (PD), including an increase in the dopamine D-2 receptor (DA-D2R), using noninvasive PET imaging with the radioligand [F-18]fallypride. The purpose of this feasibility and translational study was to examine whether intensive exercise leads to similar alterations in DA-D2R expression using PET imaging with [F-18]fallypride in individuals with early-stage PD. In this pilot study, four patients with early-stage PD were randomized to receive intensive exercise (treadmill training sessions three times/week for 8 weeks) or no exercise. Two healthy age-matched individuals participated in treadmill training. Alterations in the DA-D2R binding potential (BP) as a marker for receptor expression were determined using PET imaging with [F-18]fallypride. Turning performance in the patients with PD as a measure of postural control and the Unified Parkinson's Disease Rating Scale scores pre-exercise and postexercise were determined. Our data showed an exercise-induced increase in [F-18]fallypride BP as well as improved postural control in patients with PD who exercised. Changes in DA-D2R BP were not observed in patients with PD who did not exercise. These results suggest that exercise can lead to neuroplasticity in dopaminergic signaling and contribute to improved function that may be task specific (postural control) in early-stage PD. (C) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.