Lymph node swelling due to bacille Calmette-Guerin vaccination with multipuncture method
Lymph node swelling due to bacille Calmette-Guerin vaccination with multipuncture method
复制标题
DOI：
10.1016/s0962-8479(96)90012-x
复制
发表时间：
1996-06-01
期刊：
影响因子：
--
通讯作者：
Shiozawa, K
中科院分区：
文献类型：
--
作者：
Mori, T;Yamauchi, Y;Shiozawa, K
设置.在大规模卡介苗（BCG）接种计划中，使用多穿刺法在日本实践的幼儿，淋巴结肿胀是一种并不罕见的并发症，其管理有时是不必要的radical.Objectives：为了确定的频率淋巴结炎后卡介苗接种多穿刺法，并描述其临床特征。设计：1985 ~ 1989年对34516名0-3岁卡介苗初种儿童进行了淋巴结病的观察。向父母口头解释了淋巴结肿胀，并提供了一张带有报告表的明信片，如果在婴儿中观察到任何淋巴结肿胀，则将其退回。然后联系了父母，并邀请他们到我们的诊所进行进一步观察。结果：淋巴结肿大的发生率为0.73%（95% CI 0.65-0.83）。1岁以下婴儿发病率较高。大于10 mm的淋巴结见于0.40%的婴儿，男孩的比率高于女孩（分别为0.95%和0.50%）。65%的病例是在接种疫苗后4-6周首次发现的;其他病例是在此期间之前或之后发现的。19%的病例有多个肿大的淋巴结，2%的病例只有腋窝外的淋巴结炎。8例进展为化脓性腺炎伴破裂，占接种疫苗者的0.02%（95%CI 0.012%-0.046%）。在其余病例中，肿胀迅速消退（92%在2个月内，其他病例在2个月后），无需药物或手术治疗。
Setting. In the mass bacille Calmette-Guerin (BCG) vaccination programme using the multipuncture method practised in Japan for young children, lymph node swelling is a not uncommon complication and its management is sometimes unnecessarily radical.Objectives: To determine the frequency of lymphadenitis after BCG vaccination with the multipuncture method, and to describe its clinical features.Design: A total of 34 516 children aged 0-3 years, who received primary vaccination with BCG between 1985 and 1989, were observed for the occurrence of lymphadenopathy. Oral explanation was given to the parents about lymph node swelling, and a postcard with a reporting form was given, to be returned if any lymph node swelling was observed in the baby. The parents were then contacted, and invited to our clinic for further observation. Cases with one or more swollen nodes greater than 7 mm were included in this analysis as cases of lymphadenopathy.Results: The frequency of lymphadenopathy was 0.73% (95% CI 0.65-0.83). Babies under 1 year of age had higher incidence. Lymph nodes greater than 10 mm were seen among 0.40% of babies, with a higher rate among boys than in girls (0.95% and 0.50%, respectively). Sixty-five percent of the cases were first noticed 4-6 weeks after vaccination; others were detected before or after that period. Nineteen percent of the cases had multiple swollen nodes, and 2% had adenitis only outside the axilla. Eight cases progressed to suppurative adenitis with rupture, comprising 0.02% (95% CI 0.012%-0.046%) of those vaccinated. In the remaining cases the swelling subsided quickly (92% within 2 months and the others later), with no medical or surgical treatment.