Tumor-associated macrophage infiltration in pulmonary adenocarcinoma: Association with angiogenesis and poor prognosis
Tumor-associated macrophage infiltration in pulmonary adenocarcinoma: Association with angiogenesis and poor prognosis
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DOI：
10.1159/000012021
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发表时间：
1999-01-01
期刊：
影响因子：
3.5
通讯作者：
Kodaira, S
中科院分区：
文献类型：
--
作者：
Takanami, I;Takeuchi, K;Kodaira, S
在 113 例肺腺癌患者的标本中研究了肿瘤相关巨噬细胞 (TAM) 密度与微血管密度之间的关系，以及 TAM 密度对预后的影响。等级相关检验显示 TAM 密度和微血管密度之间存在显着关系 (y = 14.418 + 0.863x, r = 0.454, p > 0.0001)。在 TAM 密度定义为高的肿瘤和 TAM 密度定义为低的肿瘤之间检测到患者存活率存在显着差异 (p < 0.01)。多变量分析还表明，TAM 密度与生存率显着相关（p < 0.05）。这些数据表明 TAM 浸润可能有助于肿瘤血管生成，并且 TAM 密度是肺腺癌的有用预后标志物。
The relation between tumor-associated macrophage (TAM) density and the density of microvessels was investigated in specimens from 113 patients with pulmonary adenocarcinoma, as was the influence of TAM density on prognosis. The rank correlation test revealed a significant relation between TAM density and microvessel density (y = 14.418 + 0.863x, r = 0.454, p > 0.0001). A significant difference in patient survival rate was detected between tumors with a TAM density defined as high and those with a TAM density defined as low (p < 0.01). Multivariate analysis also showed that TAM density was significantly related to survival (p < 0.05). These data indicate that TAM infiltration may contribute to tumor angiogenesis, and that TAM density is a useful prognostic marker in pulmonary adenocarcinoma.