Rate of synaptic replacement in denervated rat hippocampus declines precipitously from the juvenile period to adulthood.
Rate of synaptic replacement in denervated rat hippocampus declines precipitously from the juvenile period to adulthood.
复制标题
从幼年期到成年期，去神经大鼠海马的突触替换率急剧下降。
DOI：
10.1126/science.6867730
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Lynch,G
中科院分区：
文献类型：
--
作者：
McWilliams,JR;Lynch,G
大鼠齿状回每单位面积的突触接触在出生后第一个月结束时达到成年数量，此后保持不变。这个实验表明，在损伤后突触被发芽取代的速度从35天到90天急剧下降。因此，大鼠生命的幼年期以神经元可塑性的显著变化为标志。这可能与脑损伤恢复中的年龄依赖性效应有关。
Synaptic contacts per unit area in the rat dentate gyrus reach adult numbers by the end of the first month after birth and remain constant thereafter. This experiment demonstrated that the rate at which synapses were replaced by sprouting after a lesion declined dramatically from 35 to 90 days of age. Thus, the juvenile period of the rat's life is marked by a considerable change in neuronal plasticity. This may be related to age-dependent effects in recovery from brain damage.