S-, N-, and Se-Difluoromethylation Using Sodium Chlorodifluoroacetate
S-, N-, and Se-Difluoromethylation Using Sodium Chlorodifluoroacetate
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DOI：
10.1021/ol402370f
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发表时间：
2013-10-04
期刊：
影响因子：
5.2
通讯作者：
Greaney, Michael F.
中科院分区：
文献类型：
--
作者：
Mehta, Vaibhav P.;Greaney, Michael F.
报道了一种以氯二氟乙酸为二氟甲基化试剂的硫醇二氟甲基化反应的简单方法。这种廉价的试剂在95摄氏度下进行平稳的脱羧反应，得到二氟卡宾，它可以被各种芳香族和杂芳香族硫醇捕获。该反应对杂环氮化合物和苯硒醇的二氟甲基化反应也是有效的。
A simple protocol for the difluoromethylation of thiols is reported using chlorodifluoroacetate as the difluoromethylating agent. This cheap reagent undergoes smooth decarboxylation at 95 degrees C to afford difluorocarbene, which can be trapped with a variety of aromatic and heteroaromatic thiols. The reaction is also effective for the difluoromethylation of heterocyclic nitrogen compounds and phenylselenol.