Malignancies in UK children with HIV infection acquired from mother to child transmission
Malignancies in UK children with HIV infection acquired from mother to child transmission
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DOI：
10.1136/adc.76.4.330
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发表时间：
1997-04-01
影响因子：
5.2
通讯作者：
Ades, AE
中科院分区：
文献类型：
--
作者：
Evans, JA;Gibb, DM;Ades, AE
到1995年4月，英国儿科协会监测股报告了302例垂直感染艾滋病毒的病例。超过50%的儿童患有艾滋病指标疾病，包括9种恶性肿瘤（7例非霍奇金淋巴瘤（NHL）和2例卡波西肉瘤）。还有两种恶性肿瘤不是艾滋病指标疾病。在小于5岁的儿童中，NHL的发病率约为英国儿童人群预期发病率的2500倍。三名儿童提出与NHL作为他们的艾滋病指标疾病和发展NHL的中位值为14（范围10-19）个月后，首次诊断艾滋病。7名儿童中有6名在诊断为NHL后中位数6.5（范围2-14）个月死亡。第七个孩子对治疗有反应，并且在近四年后还活着。在五个病例中可获得组织学结果，其中四个是B细胞来源，一个是T细胞来源。在所有三名NHL患者中均检测到EB病毒，所有患者均患有B细胞淋巴瘤。虽然相对罕见，但恶性肿瘤发生在感染艾滋病毒的儿童中，可能是目前的疾病。儿科医生现在需要考虑艾滋病毒感染作为儿童癌症，特别是NHL的诱发因素。
By April 1995, 302 cases of vertically acquired HIV infection had been reported through the British Paediatric Association Surveillance Unit. Over 50% of these children had developed an AIDS indicator disease, including nine malignancies (seven cases of non-Hodgkin's lymphoma (NHL) and two of Kaposi's sarcoma). There were two other malignancies that were not AIDS indicator diseases. In children less than 5 years of age the incidence of NHL was approximately 2500 times greater than expected in the UK child population. Three children presented with NHL as their AIDS indicator disease and four developed NHL at a median of 14 (range 10-19) months after the initial diagnosis of AIDS. Six of the seven children died at a median of 6.5 (range 2-14) months after the diagnosis of NHL. The seventh child responded to treatment and is alive nearly four years later Histology was available in five cases, of which four were of B cell and one of T cell origin. Epstein-Barr virus was detected in all three patients with NHL where it was sought; all had B cell lymphomas. Although comparatively rare, malignancies occur in children infected with HIV and may be the presenting illness. Paediatricians now need to consider HIV infection as a predisposing cause of childhood cancer, especially NHL.