New Approaches to Biological Pacemakers: Links to Sinoatrial Node Development.
New Approaches to Biological Pacemakers: Links to Sinoatrial Node Development.
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DOI：
10.1016/j.molmed.2015.10.002
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发表时间：
2015-12
影响因子：
13.6
通讯作者：
Vedantham V
中科院分区：
文献类型：
--
作者：
Vedantham V
心脏传导系统不可逆转的退化是一种常见的疾病，可导致运动不耐受、晕厥和死亡。虽然电子起搏器提供了有效的治疗，但当长期留置硬件不受欢迎时，需要替代方法。生物起搏器由电活动细胞组成，这些细胞在功能上与心脏整合。随着干细胞技术的发展，关于窦房结(SAN)内心脏起搏细胞(PC)的最新发现开启了生物起搏的新纪元。最近从非PC中衍生出PC样细胞的实验使这一领域比以往任何时候都更接近生物起搏器，这种起搏器可以忠实地概括SAN的活动。这篇综述在SAN生物学的背景下讨论了这些方法，并阐述了临床翻译的潜力。
Irreversible degeneration of the cardiac conduction system is a common disease that can cause activity intolerance, fainting, and death. While electronic pacemakers provide effective treatment, alternative approaches are needed when long-term indwelling hardware is undesirable. Biological pacemakers are composed of electrically active cells that functionally integrate with the heart. Recent findings on cardiac pacemaker cells (PCs) within the sinoatrial node (SAN), along with developments in stem cell technology, have opened a new era in biological pacing. Recent experiments that have derived PC-like cells from non-PCs have brought the field closer than ever before to biological pacemakers that can faithfully recapitulate SAN activity. This review discusses these approaches in the context of SAN biology and addresses the potential for clinical translation.