Plasma cortisol-dehydroepiandrosterone (DHEA) ratios in schizophrenia and bipolar disorder
Plasma cortisol-dehydroepiandrosterone (DHEA) ratios in schizophrenia and bipolar disorder
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DOI：
10.1016/j.schres.2006.11.020
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发表时间：
2007-02-01
影响因子：
4.5
通讯作者：
Ferrier, I. Nicol
中科院分区：
文献类型：
--
作者：
Gallagher, Peter;Watson, Stuart;Ferrier, I. Nicol
高糖血症是许多严重精神疾病的一个特征，已被认为是临床症状和神经认知障碍的原因和加剧因素。肾上腺类固醇脱氢表雄酮（DHEA）具有抗糖皮质激素特性，可能对脑内糖皮质激素的作用有调节作用。然而，关于这些类固醇及其在精神分裂症和双相情感障碍中的比例的数据缺乏。因此，我们试图评估精神分裂症（n=20）和双相情感障碍（n=20）患者（n=20）的皮质醇和脱氢表雄酮水平以及皮质醇与脱氢表雄酮的比值，稳定服药至少6周，健康的年龄和性别匹配的对照组（n=20）。从下午1点到4点每隔30分钟采集一次血浆样本，测量类固醇水平。与对照组相比，两组患者的皮质醇水平均显著升高。与双相患者和对照组相比，精神分裂症患者的脱氢表雄酮水平升高，但没有证据表明两组之间皮质醇-脱氢表雄酮比率有差异。这些数据表明，与对照组相比，下午高糖血症在有症状的双相情感障碍和精神分裂症患者中更为明显。然而，脱氢表雄酮水平的升高可能是精神分裂症中一种特殊的内分泌标志物。(c) 2006 Elsevier B.V.版权所有
Hypercortisolaemia is a feature of many severe psychiatric illnesses and has been suggested to be both a causal and exacerbating factor of clinical symptoms and neurocognitive impairment. The adrenal steroid dehydroepiandrosterone (DHEA) has antiglucocorticoid properties that may have regulatory effects on glucocorticoid action in the brain. However, there is a paucity of data on these steroids and their ratio in schizophrenia and bipolar disorder. We therefore sought to assess cortisol and DHEA levels and the cortisol-DHEA ratio in patients with schizophrenia (n=20) and bipolar disorder (n=20), on stable medication for a minimum of 6 weeks, and healthy age- and sex-matched control subjects (n=20). Steroid levels were measured from plasma samples collected at 30 min intervals from 1:00 p.m. to 4:00 p.m. Cortisol levels were found to be significantly elevated in both patient groups compared with controls. DHEA levels were elevated in schizophrenic patients compared with bipolar patients and controls, but there was no evidence of a difference in the cortisol-DHEA ratio of the groups. These data suggest that afternoon hypercortisolaemia is evident in symptomatic bipolar and schizophrenic patients compared to controls. However, an elevation in DHEA levels may represent a specific endocrine marker in schizophrenia. (c) 2006 Elsevier B.V. All rights reserved.