Hepatic expression of cell death-inducing DFFA-like effector C in obese subjects is reduced by marked weight loss.
Hepatic expression of cell death-inducing DFFA-like effector C in obese subjects is reduced by marked weight loss.
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DOI：
10.1038/oby.2009.236
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发表时间：
2010-02
期刊：
影响因子：
6.9
通讯作者：
Finck, Brian N.
中科院分区：
文献类型：
--
作者：
Hall, Angela M.;Brunt, Elizabeth M.;Klein, Samuel;Finck, Brian N.
细胞死亡诱导DNA片段化因子A样效应子家族（CIDEA、CIDEB和CIDEC）基因的肝脏表达在肥胖小鼠模型中显著上调。我们评估了接受胃旁路手术（GBS）的肥胖人类受试者肝脏中锡德基因的表达，在手术时和1年后再次评估，此时受试者的体重减轻了37.6 ± 1.4%。在GBS时，CIDEA（r2 = 0.20，P = 0.04）和CIDEC（r2 = 0.32，P = 0.01）的表达与BMI强相关，而CIDEB则不相关（r2 = 0.01，P = 0.81）。术后1年，CIDEC表达下降超过60%（P = 0.02），而CIDEA表达没有变化（P = 0.20）。这些数据表明，与先前在啮齿类动物中进行的研究一致，CIDEA和CIDEC（但非CIDEB）的肝脏表达在肥胖人群中增加。此外，CIDEC的肝脏表达通过显著的体重减轻而下调。
The hepatic expression of the cell death–inducing DNA fragmentation factor A–like effector family (CIDEA, CIDEB, and CIDEC) genes is markedly upregulated in mouse models of obesity. We evaluated the expression of CIDE genes in liver of obese human subjects undergoing gastric bypass surgery (GBS), at the time of surgery and again 1 year later when subjects had lost 37.6 ± 1.4% of their initial body weight. At the time of GBS, the expression of CIDEA (r2 = 0.20, P = 0.04) and CIDEC (r2 = 0.32, P = 0.01) was strongly correlated with BMI, whereas CIDEB was not (r2 = 0.01, P = 0.81). One year after surgery, CIDEC expression had declined over 60% (P = 0.02), whereas CIDEA expression did not change (P = 0.20). These data demonstrate that, consistent with previous studies conducted in rodents, hepatic expression of CIDEA and CIDEC, but not CIDEB, is increased in obese humans. Moreover, the hepatic expression of CIDEC is downregulated by marked weight loss.
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Cideb 通过控制脂肪生成和脂肪酸氧化来调节饮食引起的肥胖、肝脏脂肪变性和胰岛素敏感性
影响因子：
7.7
作者：
Li, John Zhong;Ye, Jing;Li, Peng
通讯作者：
Li, Peng
影响因子：
13.5
作者：
Kleiner, DE;Brunt, EM;Sanyal, AJ
通讯作者：
Sanyal, AJ
DOI：
10.1186/1476-5926-6-4
发表时间：
2007-05-01
期刊：
Comparative hepatology
影响因子：
--
作者：
Kelder B;Boyce K;Kriete A;Clark R;Berryman DE;Nagatomi S;List EO;Braughler M;Kopchick JJ
通讯作者：
Kopchick JJ
DOI：
10.1073/pnas.0802063105
发表时间：
2008-06-03
影响因子：
11.1
作者：
Puri, Vishwajeet;Ranjit, Srijana;Czech, Michael P.
通讯作者：
Czech, Michael P.
影响因子：
4.8
作者：
Puri, Vishwajeet;Konda, Silvana;Czech, Michael P.
通讯作者：
Czech, Michael P.