Functional changes in dopamine D3 receptors by prenatal and neonatal exposure to an endocrine disruptor bisphenol‐A in mice
Functional changes in dopamine D3 receptors by prenatal and neonatal exposure to an endocrine disruptor bisphenol‐A in mice
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DOI：
10.1080/13556210410001674059
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发表时间：
2004-03
影响因子：
3.4
通讯作者：
K. Mizuo;M. Narita;Takuya Yoshida;Michiko Narita;Tsutomu Suzuki
中科院分区：
文献类型：
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作者：
K. Mizuo;M. Narita;Takuya Yoshida;Michiko Narita;Tsutomu Suzuki
双酚 A (BPA) 是最常见的环境内分泌干扰物之一，其毒性和致癌性已被广泛评估。然而，人们对其对中枢神经系统（CNS）的作用仍知之甚少。在之前的研究中，我们发现产前和新生儿接触BPA显着增强吗啡引起的奖赏效应。在这里，我们发现产前和新生儿接触 BPA 会导致小鼠边缘前脑中 7-OH-DPAT 介导的多巴胺 D3 受体介导的 G 蛋白激活减弱。这种治疗还导致该区域的多巴胺 D3 受体配体 [3H]PD128907 的 B max 值显着降低。在这些条件下，未观察到产前和新生儿暴露于 BPA 导致边缘前脑和下中脑的多巴胺 D3 受体 mRNA 表达发生变化。目前的数据进一步证明，产前和新生儿接触 BPA 会导致功能性多巴胺 D3 受体减少，而不影响小鼠边缘前脑中多巴胺 D3 受体的新合成。
Bisphenol‐A (BPA), one of the most common environmental endocrine disrupters, has been evaluated extensively for toxicity and carcinogenicity. However, little is still known about its action on the central nervous system (CNS). In the previous study, we found that prenatal and neonatal exposure to BPA markedly enhanced the rewarding effect induced by morphine. Here we found that prenatal and neonatal exposure to BPA resulted in the attenuation of dopamine D3 receptor‐mediated G‐protein activation by 7‐OH‐DPAT in the mouse limbic forebrain. This treatment also caused a significant decrease in the B max value of [3H]PD128907, a dopamine D3 receptor ligand, in this area. Under these conditions, no change in dopamine D3 receptor mRNA expression in the limbic forebrain and lower midbrain was observed by prenatal and neonatal exposure to BPA. The present data provide further evidence that prenatal and neonatal exposure to BPA leads to the reduction of functional dopamine D3 receptors without affecting the new synthesis of dopamine D3 receptors in the mouse limbic forebrain.