DETERMINANTS OF GENITAL HUMAN PAPILLOMAVIRUS INFECTION AMONG CYTOLOGICALLY NORMAL WOMEN ATTENDING THE UNIVERSITY-OF-NEW-MEXICO STUDENT HEALTH-CENTER
DETERMINANTS OF GENITAL HUMAN PAPILLOMAVIRUS INFECTION AMONG CYTOLOGICALLY NORMAL WOMEN ATTENDING THE UNIVERSITY-OF-NEW-MEXICO STUDENT HEALTH-CENTER
复制标题
DOI：
10.1097/00007435-199309000-00009
复制
发表时间：
1993-09-01
影响因子：
3.1
通讯作者：
MANOS, MM
中科院分区：
文献类型：
--
作者：
WHEELER, CM;PARMENTER, CA;MANOS, MM
目的：为了确认生殖器人乳头瘤病毒（HPV）感染的危险因素，本研究的目的：“调查HPV检测的危险因素，除了宫颈肿瘤的相关危险因素。研究设计：宫颈人乳头瘤病毒（HPV）DNA进行了评估，在357名细胞学正常的妇女参加了新墨西哥州学生健康中心。宫颈拭子样本用于HPV DNA检测和分型，使用基于PCR的DNA扩增系统。宫颈HPV的可能的决定因素进行了检查，包括年龄，种族，性传播疾病史，口服避孕药的使用，吸烟，首次性交的年龄，一生中的性伴侣数量，婚姻状况，和怀孕historyoffering.Results：观察到宫颈HPV的总患病率为44.3%。在单变量分析中，与HPV患病率增加相关的因素包括性伴侣数量和单身婚姻状况。在调整了潜在的混杂变量后，我们发现HPV的患病率随着一生中性伴侣数量的增加而增加。结论：这些发现，沿着这期杂志的相关报道，支持了病毒的性传播途径。
Objectives: To confirm the risk factors for genital human papillomavirus (HPV) infection.Goal of this study:' To investigate risk factors for HPV detection apart from the correlated risk factors for cervical neoplasia.Study Design: Cervical human papillomavirus (HPV) DNA was assessed in 357 cytologically normal women attending the University of New Mexico student health center. Cervical swab samples were obtained for HPV DNA detection and typing using a PCR-based DNA amplification system. Possible determinants of cervical HPV were examined including age, ethnicity, history of sexually transmitted disease, oral contraceptive use, smoking, age at first intercourse, lifetime number of sex partners, marital status, and history of pregnancy.Results: A 44.3% overall prevalence of cervical HPV was observed. On univariate analysis, factors associated with increasing HPV prevalence included higher lifetime number of sex partners and single marital status. After adjustment for potential confounding variables, we found that HPV prevalence increased with higher lifetime number of sexual partners.Conclusion: These findings, along with those from the companion reports in this issue of the journal, support the sexual route of transmission of the virus.