Harsh parenting and youth systemic inflammation: Modulation by the autonomic nervous system.
Harsh parenting and youth systemic inflammation: Modulation by the autonomic nervous system.
复制标题
DOI：
10.1037/hea0000852
复制
发表时间：
2020-03
期刊：
影响因子：
--
通讯作者：
A. Oshri;E. Duprey;Sihong Liu;Katherine B. Ehrlich
中科院分区：
文献类型：
--
作者：
A. Oshri;E. Duprey;Sihong Liu;Katherine B. Ehrlich
目的探讨自主神经系统（ANS）在家庭压力对青少年炎症的影响中的调节作用。首先，我们研究了不良养育行为的严重程度对青年中两种全身性炎症血清生物标志物（C反应蛋白和白细胞介素-6）的直接影响。其次，我们测试了ANS反应性在应对实验室诱导的压力中的调节作用，这些青年中严厉的养育和炎症之间的关联。方法样本包括101名低收入儿童（75.2%非裔美国人），年龄在9至12岁之间（法师= 10.9; SDage = 1.2），他们在实验室环境中与主要照顾者一起参与了冲突任务。心率变异性反应性（HRV-R），皮肤电导水平反应性（SCL-R），射血前期反应性（PEPr-R）被用来指数副交感神经和交感神经系统的反应性。从血清中获得低度炎症标志物（C-反应蛋白和白细胞介素-6）。调整混杂变量后，ANS活动调节了家庭压力和全身炎症之间的关系。具体而言，HRV-R升高缓冲了家庭压力对青少年炎症的影响，而PEPr-R和SCL-R升高则加剧了这种影响。结论ANS功能提示自我调节能力和威胁敏感性可能对家庭应激与全身炎症的关系有影响。（PsycInfo数据库记录（c）2020阿帕，保留所有权利）。
OBJECTIVE The present study aimed to test the role of the autonomic nervous system (ANS) in modulating the impact of family stress induced by harsh parenting on youths' inflammation. First, we examined the direct effect of severity of adverse parenting behaviors on two serum biomarkers of systemic inflammation (C-reactive protein and interleukin-6) among youth. Second, we tested the moderating role of ANS reactivity in response to laboratory-induced stress in the association between harsh parenting and inflammation among these youth. METHOD The sample included 101 low-income children (75.2% African American) between 9 and 12 years of age (Mage = 10.9; SDage = 1.2) who participated in a conflict task with their primary caregiver in a laboratory setting. Heart rate variability reactivity (HRV-R), skin conductance level reactivity (SCL-R), and preejection period reactivity (PEPr-R) were used to index parasympathetic and sympathetic nervous system reactivity. Markers of low-grade inflammation (C-reactive protein and interleukin-6) were obtained from serum. RESULTS After adjusting for confounding variables, ANS activity moderated the associations between family stress and systemic inflammation. Specifically, elevated HRV-R buffered the effect of family stress on youths' inflammation, whereas elevated PEPr-R and SCL-R exacerbated the effect. CONCLUSION These findings show that self-regulatory capacity and threat sensitivity, as indicated by ANS function, may have an impact on the associations between family stress and systemic inflammation. (PsycInfo Database Record (c) 2020 APA, all rights reserved).