Increased regional homogeneity of blood oxygen level-dependent signals in occipital cortex of early blind individuals
Increased regional homogeneity of blood oxygen level-dependent signals in occipital cortex of early blind individuals
复制标题
早期失明者枕叶皮层血氧水平依赖性信号的区域均匀性增加
DOI：
10.1097/wnr.0b013e3283447c09
复制
发表时间：
2011-03-09
期刊：
影响因子：
1.7
通讯作者：
Yu, Chunshui
中科院分区：
文献类型：
--
作者：
Liu, Chong;Liu, Yong;Yu, Chunshui
尽管静息态功能磁共振成像已显示早期失明个体的视觉区域和其他脑区之间的功能连接发生改变，但它无法回答哪些脑区的局部活动发生了变化。在这项研究中，局部一致性（一种衡量局部血氧水平依赖信号同质性的指标）首次被用于研究早期失明个体静息态脑活动的变化。与年龄和性别匹配的有视力个体相比，早期失明个体仅在枕叶区域表现出局部一致性增加，这可能是由于早期视觉剥夺导致的皮质发育异常和/或经验依赖性可塑性所造成的。《神经报告》22:190 - 194（C）2011年，威科集团 | 利平科特·威廉姆斯和威尔金斯出版社。
Although resting-state functional magnetic resonance imaging has shown altered functional connectivity between visual and other brain areas in the early blind individuals, it cannot answer which brain area's local activities arechanged. In this study, regional homogeneity, a measure of the homogeneity of the local blood oxygen level-dependent signals, was used for the first time to investigate the changes in the resting-state brain activity in the early blind individuals. Compared with age-matched and sex-matched sighted individuals, the early blind individuals showed increased regional homogeneity only in the occipital areas, which might be explained by the abnormal cortical development and/or experience-dependent plasticity, resulted from an early visual deprivation.