Dispersion patterns of clonally related cells during development of the hypothalamus
Dispersion patterns of clonally related cells during development of the hypothalamus
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DOI：
10.1006/dbio.1996.0013
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发表时间：
1996-01-10
影响因子：
2.7
通讯作者：
Cepko, CL
中科院分区：
文献类型：
--
作者：
ArnoldAldea, SA;Cepko, CL
为了确定下丘脑早期发育过程中细胞生成和迁移的模式，用逆转录病毒载体文库对克隆进行了标记。胚胎8-10天分析的克隆大多为简单的径向柱状。少数克隆人有三种不寻常的扩散模式之一。一种不同寻常的克隆类型是腹侧前脑两侧对称的。另一种是由沿脑室表面排成一条线的四列或更多列细胞组成，第三种是由平行于脑室表面的平面上典型的放射状柱状分散的细胞组成。这些稀有克隆的出现表明，在腹侧前脑的早期发育过程中，存在不同的克隆分散机制，这些机制可能在下丘脑的模式形成中发挥作用。(C)1996年学术出版社。
To identify patterns of cell generation and migration during early development of the hypothalamus, clones were marked with a library of retroviral vectors. The majority of clones analyzed at Embryonic Days 8-10 were simple radial columns. A small number of clones had one of three unusual patterns of dispersion. One unusual clone type was bilaterally symmetric across the ventral forebrain. Another was composed of four or more columns of cells arranged in a line along the ventricular surface, and a third was composed of cells that appeared to disperse from the typical radial columns in a plane parallel to the ventricular surface. The appearance of the rare clones suggests that there are different mechanisms of clonal dispersion during early development of the ventral forebrain that could play a role in patterning the hypothalamus. (C) 1996 Academic Press, Inc.