Rectal microbicide acceptability.: Results of a volume escalation trial
Rectal microbicide acceptability.: Results of a volume escalation trial
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DOI：
10.1097/01.olq.0000233715.59239.83
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发表时间：
2007-04-01
影响因子：
3.1
通讯作者：
Mayer, Kenneth H.
中科院分区：
文献类型：
--
作者：
Carballo-Dieguez, Alex;Exner, Theresa;Mayer, Kenneth H.
目的：本研究的目的是确定接受性肛交（RAI）前直肠内使用多少体积的杀微生物剂安慰剂凝胶是可接受的；并评估对凝胶性质的反应，它的应用，以及它的用途。研究设计：报告无保护RAI且伴血清不一致或身份不明伴侣的hiv未感染男性被纳入容量递增试验。结果：大多数参与者可以接受高达35 mL具有Femglide物理特性（透明无味）的凝胶。可能需要选择不同级别的粘度。对于一些男性来说，在没有性交的情况下使用的音量被认为是可以接受的，而在性交时使用的音量被认为是不可接受的。总的来说，参与者报告说，如果有杀菌剂，他们很愿意使用。尽管建议使用避孕套，但使用避孕套的情况并不一致。结论：对于从事高危RAI的男性，需要高达35ml体积的杀菌剂才能有效是可以接受的。
Objectives: The objectives of this study were to determine what volume of a microbicide placebo gel is acceptable when applied intrarectally before receptive anal intercourse (RAI); and to evaluate responses to properties of the gel, its application, and its use.Study Design: HIV-uninfected men who reported unprotected RAI with serodiscordant or unknown-status partners were enrolled in a volume escalation trial.Results: Up to 35 mL of gel with the physical properties of Femglide (transparent and odorless) was acceptable to the majority of participants. Choice of different levels of viscosity may be needed. For some men, volumes judged acceptable when tried without intercourse were not acceptable when used during sex. Overall, participants reported high intentions to use microbicides when available. Condom use was inconsistent despite advice to use condoms.Conclusions: Microbicides that would require up to 35 mL of volume to be effective would be acceptable to men who engage in high-risk RAI.